Endometrial Cancer
Conditions
Keywords
endometrial cancer, miRNA, microRNA, TGCA
Brief summary
The TCGA project identified four distinct prognostic groups of endometrial carcinoma (EC) based on molecular alterations: (i) the ultramutated subtype that encompasses POLE mutated (POLE) cases; (ii) the hypermutated subtype, characterized by MisMatch Repair deficiency (MMRd); (iii) the copy-number high subtype, with p53 abnormal/mutated features (p53abn); (iv) the copy-number low subtype, known as No Specific Molecular Profile (NSMP). Although the prognostic value of TCGA molecular classification, NSMP carcinomas present a wide variability in molecular alterations and biological aggressiveness. Given that the study aims to evaluate the miRNA expression profile to identify novel potential biomarkers to better stratify the EC patients, taking into account the molecular status
Interventions
None listed
Sponsors
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* age\>18yo * histological diagnosis of endometrial cancer * tumor resection * patient's informed consent
Exclusion criteria
* patients with other neoplasia within the last 5 years
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Evaluation of miRNA expression based on the 4 molecular groups | 1 year | Evaluate miRNA expression based on the 4 molecular groups recently identified |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Integration of molecular results with clinico-pathological data | 1 year | Integration of molecular results with clinico-pathological data |
Countries
Italy
Contacts
Primary ContactAnna Myriam Perrone, MD
Backup ContactAnna Myriam Perrone
Outcome results
None listed