Copd
Conditions
Keywords
beta blockers -nebivolol
Brief summary
To Evaluate the Outcome of cardio selective beta1 (β1-) blockers use in patients with chronic obstructive pulmonary disease. Patient education about the COPD and their medications.
Detailed description
Chronic obstructive pulmonary disease (COPD) is a common preventable and Treatable airway disorder characterized by symptoms such as dyspnea, chronic Cough, and sputum production along with persistent airflow limitation that is not fully Reversible. Evidence provided by post hoc analysis of clinical trials and large observational studies suggests a beneficial effect of beta-blockers on mortality and exacerbation in mild to moderate COPD patients. Evidence concerning cardio selective B blockers. Over the past 20 years' non selective B blockers have largely been replaced with cardio selective blockers. Cardio selective beta blockers such as atenolol and metoprolol are at least 20 times more potent at blocking B-1 receptors than B-2 receptors. At therapeutic doses the B-1 blocking effect, and therefore the risk of bronco constriction, is negligible. In addition there is strong evidence that B-blocked cause up-regulation and sensitization of B-receptors.
Interventions
DRUGNebivolol Tablets
cardio selective beta-1 blocker
Sponsors
Ain Shams University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
40 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
1. Male or female. 2. informed consent. 3. Age \>40years. 4. FEVl/FVC\<70%. 5. diagnosed 3 month before enrollment (mild-moderate) 6. Reversability test pre-post bronchodilators FEVl predicted\<200ml/hr and less than 12%.
Exclusion criteria
1. Asthmatic patient. 2. patient already use B blockers. 3. Acute exacerbation. 4. Pregnency -lactation. 5. Advanced cardiac, renal or liver disease according to investigator opinion.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| forced vital capacity | 3 months | amount of air that can be forcibly exhaled from the lung after taking the deepest breath possible (FVC\\liter) |
| forced expiratory volume in one second | 3 month | volume of air exhaled under condition in the first second (FEV1\\liter) |
| blood pressure | 3 month | BP millimetre mercury |
Countries
Egypt
Contacts
Primary Contactasma suliman, bachelor
Backup Contactmarwa adel, associated professor
Outcome results
None listed