Neurodevelopmental Disorders, Premature Birth
Conditions
Brief summary
This project aims to measure repetition suppression and tactile prediction using high-resolution electroencephalography in preschoolers, in order to describe the responses as a function of age, gestational age of birth and the presence of a neurodevelopmental disorder. We will include 100 children aged 2 or 6 years: 25 2-year-olds born prematurely, 25 2-year-olds born at term, 25 6-year-olds with typical development and 25 6-year-olds with neurodevelopmental disorders. We will perform several behavioral evaluations to analyze the results in view of the quality of development.
Detailed description
We will include 100 children aged 2 or 6 years: 25 2-year-olds born prematurely, 25 2-year-olds born at term, 25 6-year-olds with typical development and 25 6-year-olds with neurodevelopmental disorders. Children will be recruited from local schools and institutions. Birth will be considered premature if children were born before 36 weeks of gestational age. Children will be considered as having neurodevelopmental disorder if they receive medical and/or paramedical care at the time of measurement for neurodevelopmental disorder, including autism spectrum disorder, attention deficit with or without hyperactivity, tics, learning disorders, but all participants must be attending school at the time of measurement. Children will come to the lab for a 2 hours session with their parents, during which they will undergo movement, attention and executive functions evaluations. Parents will fill out questionnaires evaluating their child's executive functioning and sensory profile in home/everyday settings. Children will then be equipped with 128-channels electroencephalography and proposed two tests : a modified attention network task and a tactile prediction task. We will calculate correlations between evoked potential amplitudes during the tactile prediction trials and inhibitory conflict trials. Results will be analysed in the light of age, gestational age at birth, ecological and psychometric evaluations, and neurodevelopmental status.
Interventions
DEVICEelectroencephalography
128-channel electroencephalography
DEVICETactile stimulation
Vibrotactile sequence on the forearm
BEHAVIORALAttention Network task (computerized)
Computer-based game challenging orienting and executive attention. The subject must chose which side an animal is going, using left and right buttons, depending on the validity of a cue and the congruency of flankers.
BEHAVIORALHead-toes-knees-schoulders
Following motor commands such as touch your head when they are congruent or incongruent.
BEHAVIORALLaby 5-12
Test of motor planning using labyrinths
BEHAVIORALM-ABC 2
Test of motor functions using various subtests of gross and fine motor function.
BEHAVIORALStroop animals
Stroop test for preK children using animals instead of words
Sponsors
University Hospital, Caen
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
2 Years to 6 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 24 to 35 or 72 to 83 months * Born prematurely or term, with or without neurodevelopmental disorders (see arms) * Parental informed consent * Attending school
Exclusion criteria
* Severe IQ deficit or language impairment * Psychotropic medication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Tactile prediction at 2 | 2 years | Difference of amplitude between baseline and omission segment |
| Tactile prediction at 6 | 6 years | Difference of amplitude between baseline and omission segment |
| Repetition suppression at 2 | 2 years | Difference of tactile evoked potential amplitude between end and beginning of stimulation sequence |
| Repetition suppression at 6 | 6 years | Difference of tactile evoked potential amplitude between end and beginning of stimulation sequence |
Countries
France
Contacts
Primary ContactNadege Roche-Labarbe, PhD
Outcome results
None listed