Blood Pressure
Conditions
Keywords
salt sensitivity, salt, acute salt sensitivity, Blood pressure, Mean arterial pressure
Brief summary
Dietary salt raises blood pressure in certain individuals immediately after ingestion (acute salt sensitivity; ASS) while not affecting others. It is hypothesized that ASS is a risk factor for hypertension. However, no thresholds or diagnostic guideline is available for ASS. This study is the first aim in the main study (HIPO CAP DITSH Study) aimed at determining the threshold or blood pressure cut-offs for ASS upon ingesting dietary salt.
Interventions
DIETARY_SUPPLEMENTdietary salt
2 grams of dietary salt
Sponsors
University of Zambia
Mulungushi University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Intervention model description
Time series design
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Adults aged 18 years and above. Normotensive. If Hypertensive (should be off antihypertensive medication at least 2 weeks prior to the study)
Exclusion criteria
* diabetes patients, ill participants
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Acute salt sensitivity | 160 minutes | Mean arterial pressure change of 10 mmHg |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Diastolic blood pressure change | 160 minutes | Diastolic blood pressure change of equal to or more than 10 mmHg |
| Systolic blood pressure change | 160 minutes | Systolic blood pressure change of equal to or more than 20 mmHg |
Countries
Zambia
Outcome results
None listed