Haemodialysis, Kidney Transplantation, Pulmonary Hypertension
Conditions
Keywords
pulmonary hypertension, kidney transplantation, vascular remodeling, echocardiography, pulmo-renal axis
Brief summary
The aim of the study is to investigate pulmonary hemodynamics at rest and during exercise in patients before and after kidney transplantation.
Interventions
DIAGNOSTIC_TESTexercise echocardiography
All patients will undergo exercise echocardiography during a symptom-limited cardiopulmonary exercise test.
Sponsors
Janssen-Cilag G.m.b.H
Medical University of Graz
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age: ≥ 18 years * patients listed for first kidney transplantation at the Clinical Division of Nephrology
Exclusion criteria
* Age \< 18 years * combined organ transplantations (heart-kidney, pancreas-kidney etc.) * patients with prior kidney transplantation * high calcium score on cardiac-CT (\> 160 Agatston Score)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in the systolic pulmonary arterial pressure/cardiac output (SPAP/CO) slope | Baseline and 1 year after kidney transplantation | Change in the systolic pulmonary arterial pressure/cardiac output (SPAP/CO) slope (calculated as the difference of maximal and resting SPAP divided by the difference of maximal and resting CO) before versus one year after kidney transplantation assessed by exercise echocardiography |
Secondary
| Measure | Time frame |
|---|---|
| Change in systolic pulmonary arterial pressure at rest before versus one year after kidney transplantation assessed by (exercise) echocardiography | Baseline and 1 year after kidney transplantation |
| Change in systolic pulmonary arterial pressure at 25 Watts before versus one year after kidney transplantation assessed by (exercise) echocardiography | Baseline and 1 year after kidney transplantation |
| Change in mean pulmonary arterial pressure at rest before versus one year after kidney transplantation | Baseline and 1 year after kidney transplantation |
| Change in mean pulmonary arterial pressure during exercise before versus one year after kidney transplantation | Baseline and 1 year after kidney transplantation |
| Change in pulmonary vascular resistance at rest before versus one year after kidney transplantation | Baseline and 1 year after kidney transplantation |
| Change in pulmonary vascular resistance during exercise before versus one year after kidney transplantation | Baseline and 1 year after kidney transplantation |
| Change in pulmonary arterial wedge pressure at rest before versus one year after kidney transplantation | Baseline and 1 year after kidney transplantation |
| Change in pulmonary arterial wedge pressure during exercise before versus one year after kidney transplantation | Baseline and 1 year after kidney transplantation |
| Change in cardiac output at rest before versus one year after kidney transplantation | Baseline and 1 year after kidney transplantation |
| Change in cardiac output during exercise before versus one year after kidney transplantation | Baseline and 1 year after kidney transplantation |
Countries
Austria
Outcome results
None listed