Furcation Treatment With L-PRF and aPDT

Evaluation of Leukocyte Platelet Rich Fibrin With Antimicrobial Photodynamic Therapy in Treatment of Furcation Involvement: Randomised Clinical Study

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04842188

Enrollment

Registered

2021-04-13

Start date

2020-07-28

Completion date

2021-04-30

Last updated

2021-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Furcation Defects

Keywords

platelet rich fibrin, photodynamic therapy

Brief summary

To treat grade II periodontally diseased furcation areas Leukocyte-Platelet Rich Fibrin (L-PRF) combined with antimicrobial Photo-Dynamic Therapy (a-PDT) was used.

Detailed description

randomized, triple-blinded study (patient, clinician and biostatistician). Twenty-four patients with Grade II furcation involvement were recruited in this study. Control group only received L-PRF, while study group used a combination of L-PRF and aPDT Attachment level, pocket depth, horizontal component and gingival recession, also radiographic Bone depth, width, height and volume were were recorded at baseline and postoperatively after 6 months

Interventions

PROCEDUREL-PRF with aPDT

surgical open flap debridement followed by L-PRF with aPDT

PROCEDUREL-PRF

surgical open flap debridement followed by L-PRF alone

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

32 Years to 48 Years

Healthy volunteers

Yes

Inclusion criteria

* Grade II furcation involvement * age range 18- 50 years * 3 mm or more vertical probing depth

Exclusion criteria

* systemic disease * abnormal clotting and bleeding * smokers, * root caries or restoration * Grade II mobility * periapical lesions

Design outcomes

Primary

Measure	Time frame	Description
Clinical evaluation of Vertical clinical attachment level VCAL	6 months	using periodontal probe in mm
clinical evaluation of vertical pocket depth VPD	6 months	using periodontal probe in mm
clinical evaluation of furcation horizontal component FHC	6 months	using periodontal probe in mm
clinical evaluation of gingival recession REC	6 months	using periodontal probe in mm

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026