Pituitary Adenoma
Conditions
Brief summary
This study evaluates the structural parameters, by spectral domain optical coherence tomography (OCT), retinal vessel density, using OCT angiography, and visual acuity in patients that received endoscopic endonasal approach for the removal of an intra-suprasellar pituitary adenoma compressing the optic nerve.
Detailed description
The primary outcome was to detect the changes in visual acuity, retinal structural and vascular features at 48 hours and 1 year after Endoscopic Endonasal Approach for the removal of an intra-suprasellar pituitary adenoma compressing the optic nerve. The secondary outcome was to identify potential biomarker that could predict the functional recovery at 1 year follow up.
Interventions
Surgical treatment consisted of an endoscopic endonasal approach using a rigid 0-degree endoscope, 18 cm in length and 4 mm in diameter.
Sponsors
Federico II University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
40 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* age older than 40 years * diagnosis of pituitary adenoma * treatment-naïve with Endoscopic Endonasal Pituitary Surgery * absence of other neurological diseases * absence of vitreoretinal and vascular retinal diseases
Exclusion criteria
* age younger than 40 years * No diagnosis of pituitary adenoma * previous treatments with Endoscopic Endonasal Pituitary Surgery * presence of neurological diseases * presence of vitreoretinal and vascular retinal diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Comparison between retinal structures before and 48 hours and 1 year after Endoscopic Endonasal Pituitary Surgery | 48 hours and 1 year follow up | 8 patients with pituitary adenoma compressing optic chiasm. Changes in thickness of ganglion cell complex (microns) and in thickness of retinal nerve fiber layer (microns) before and 48 hours and 1 year after Endoscopic Endonasal Pituitary Surgery |
| Comparison between retinal microvasculature before and 48 hours and 1 year after Endoscopic Endonasal Pituitary Surgery | 48 hours and 1 year follow up | 8 patients with pituitary adenoma compressing optic chiasm. Changes in retinal vessel density (percent) in macular and papillary regions before and 48 hours and 1 year after Endoscopic Endonasal Pituitary Surgery |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Correlation between retinal structures and visual acuity after Endoscopic Endonasal Pituitary Surgery | 1 year follow up | 8 patients with pituitary adenoma compressing optic chiasm underwent Endoscopic Endonasal Pituitary Surgery. Correlation between ganglion cell complex, retinal nerve fiber layer thicknesses (microns) at baseline and visual acuity recovery (logMAR) 1 year after surgery. |
| Correlation between retinal microvasculature and visual acuity after Endoscopic Endonasal Pituitary Surgery | 1 year follow up | 8 patients with pituitary adenoma compressing optic chiasm underwent Endoscopic Endonasal Pituitary Surgery. Correlation between retinal vessel density (percent) at baseline and visual acuity recovery (logMAR) 1 year after surgery. |
Countries
Italy
Outcome results
None listed