Chronic Obstructive Pulmonary Disease
Conditions
Keywords
neural respiratory drive, Intrinsic Positive End-expiratory Pressure, Chronic Obstructive Pulmonary Disease Patients
Brief summary
To investigate the relation the nreural drive and intrinsic positive end-expiratory pressure(PEEPi) of the chronic obstructive pulmonary disease(COPD) patients with respiratory failure.In present study the PEEPi of COPD patients was increased by increasing the resistance of the respiratory system, the change of the neural drive was recorded.
Detailed description
To investigate the relation the nreural drive and intrinsic positive end-expiratory pressure(PEEPi) of the chronic obstructive pulmonary disease(COPD) patients with respiratory failure.The diaphragm electromyogram (EMGdi) represents the neural drive to the diaphragm.A multi-pair esophageal electrode catheter was used to record the EMGdi.The PEEPi was assessed by the by the balloon-catheter in the multi-pair esophageal electrode catheter. In present study the PEEPi of COPD patients was increased by increasing the resistance of the respiratory system, the change of the neural drive( EMGdi) was obtained from the a multi-pair esophageal electrode catheter All the signal recorded in the computer. The relation the nreural drive assessed by EMGdi and intrinsic positive end-expiratory pressure(PEEPi) would be analysed.
Interventions
OTHERResistance of the respiratory system
increase the resistance of the respiratory system of the chronic obstructive pulmonary disease patients
Sponsors
The First Affiliated Hospital of Guangzhou Medical University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Intervention model description
the chronic obstructive pulmonary disease patients with respiratory failure
Eligibility
Sex/Gender
MALE
Age
50 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
chronic obstructive pulmonary disease patients with respiratory failure
Exclusion criteria
1. Heart failure 2. cardiac dysrhythmia 3. Loss of consciousness
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| neural respiratory drive assessed by the root mean square of diaphragm electromyogram (EMGdi) of the chronic obstructive pulmonary disease patients with respiratory failure | 1 hour | neural respiratory drive assessed by the root mean square of diaphragm electromyogram (EMGdi) obtained from the a multi-pair esophageal electrode catheter |
Countries
China
Outcome results
None listed