Urologic Cancer
Conditions
Brief summary
This study will be done to investigate perioperative lidocaine infusion on neutrophil extracellular trapping in the patients undergoing the robot-assisted prostatectomy.
Detailed description
Neutrophil extracellular trapping by analyzing the meyloperoxidase, neutrophil elastase, citrullinated histone3
Interventions
DRUGlidocaine group
lidocaine 1.5 mg/kg bolus (infused over 10 min) followed by 2.0 mg/kg/h during operation and 1.0 mg/kg/h during postoperative 24 hours (no more than 120 mg/h)
DRUGcontrol group
normal saline 0.15 ml bolus followed by 0.2 ml/kg/hr during operation and 0.1 ml/kg/hr during postoperative 24 hours
Sponsors
The Catholic University of Korea
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
20 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* patients scheduled robot-assisted prostatectomy
Exclusion criteria
* lidocaine allergy Hx * hemodynamic unstable patients * weight \< 40kg * arrhythmia or bradycardia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Concentration of citrullinated histone3 | 24 hours after surgery | This will be obtained using ELISA. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Concentration of meyloperoxidase | 24 hours after surgery | This will be obtained using ELISA. |
| Concentration of neutrophil elastase | 24 hours after surgery | This will be obtained using ELISA. |
Other
| Measure | Time frame | Description |
|---|---|---|
| the severity of postoperative pain using NRS | during postoperative 24 hours | This will be measured using NRS (numeric rating scale; 0=no pain, 10=the worst pain) |
Countries
South Korea
Outcome results
None listed