Dietary Exposure, Metabolic Disturbance
Conditions
Keywords
cherry, anthocyanin, vascular function, metabolomics
Brief summary
Diets containing fruit rich in anthocyanins have been shown (in meta-analyses) to be beneficial for health, but intervention trials have shown inconsistent results. In this preliminary study we want to investigate the influence of a tart-cherry juice intervention on vascular function and explore metabolite profiles that may offer insight into their mechanism of action
Detailed description
Cardiovascular disease (CVD) is the primary cause of morbidity and mortality. Tart cherries (TC) can positively impact major risk factors of CVD, activities thought to be related to their phytochemical content. However, data from human trials is less clear. TC have been shown to reduce systolic blood pressure (SBP) after acute, short-term and chronic intake, and to improve vascular dysfunction, presumably due to their antioxidant and anti-inflammatory activities. Other studies have not shown benefits of TC on SBP or vascular function and studies are difficult to interpret with different populations, dosing and durations being used as well as a lack of understanding for any underlying mechanisms. To account for the latter, the use of metabolomics has become increasingly popular in nutritional research. Therefore, the aim of this preliminary study was to characterise the effects of TC supplementation on vascular function with a 4-week intervention and explore if metabolomics can provide mechanistic evidence and this will inform for future chronic studies with TC juice.
Interventions
DIETARY_SUPPLEMENTCherry juice
A tart cherry juice intervention
DIETARY_SUPPLEMENTPlacebo
A tart cherry juice placebo
Sponsors
Northumbria University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Masking description
Participants supplied with treatment or placebo in a plastic container
Intervention model description
Randomised controlled trial
Eligibility
Sex/Gender
ALL
Age
19 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* aged 19-40 * no diagnosed issues with the ability to consume fruit juice * no known food intolerances to fruits
Exclusion criteria
* participants that are cigarette smokers * participants diagnosed with hypertension * participants diagnosed with any form of cardiometabolic diseases * participants that require any prescribed prescriptions excluding the contraceptive pill * participants that are regular consumers of cherries (\>100 g/d) * participants that consume any antioxidant supplements
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Systolic and diastolic blood pressure | Change in blood pressure following 4 weeks intervention | Measurement of systolic and diastolic blood pressure before and after the intervention |
| Arterial pulse wave velocity | Change in pulse wave velocity following 4 weeks intervention | Measurement of pulse wave velocity before and after the intervention |
| Digital volume pulse | Change in digital volume pulse following 4 weeks intervention | Measurement of digital volume pulse before and after the intervention |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Metabolomics | Changes to urinary metabolite profiles following 4 weeks intervention | Ion intensities of ca 5000 metabolites in urine samples before and after the intervention |
Countries
United Kingdom
Outcome results
None listed