Personalizing Window of Implantation During Frozen Embryo Transfer

ADHESIORT - Personalizing Window of Implantation During Frozen Embryo Transfer

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04840121

Acronym

AdhesioRT

Enrollment

120

Registered

2021-04-09

Start date

2021-03-24

Completion date

2024-01-29

Last updated

2024-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fertility

Brief summary

Embryo implantation is a crucial event in the establishment of a pregnancy. Although the clinical and culture conditions to obtain a good quality embryo are well advanced today, endometrial receptivity remains a major barrier in assisted reproductive techniques. Once a high-quality embryo is transferred, impaired uterine receptivity is believed to be one of the major reasons behind failure of the establishment of pregnancy.

Interventions

DIAGNOSTIC_TESTAdhesioRT

AdhesioRT, a novel diagnostic genetic assay, developed by ovo R&D scientists, helps to predict the endometrial receptivity and embryo implantation.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

NONE

Intervention model description

Participants will be randomized in either the study group - AdhesioRT or in the control group - standard of care. All participants recruited, including the control group, will have the AdhesioRT biopsies performed.

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 40 Years

Healthy volunteers

Inclusion criteria

* Women between the ages of 18 to 40 inclusive at the time of oocyte retrieval * Prescription of a single frozen embryo transfer - substituted cycle protocol * Participant has at least 2 vitrified good quality blastocysts

Exclusion criteria

* Women undergoing fertility preservation * Stage IV severe endometriosis * Severe malformation, adenomyosis or uterine anomaly including fibroids deforming the uterine cavity ≥ 5 cm * Positive results of screening for either participant or partner for HIV antibodies, Hepatitis B (other than surface antibodies present after vaccination) or Hepatitis C

Design outcomes

Primary

Measure	Time frame	Description
Determination of appropriate window of implantation	14 days after embryo transfer	Comparison between standard frozen embryo transfer and personalized frozen embryo transfer using AdhesioRT to determine a successful window of implantation

Secondary

Measure	Time frame	Description
Rate of clinical pregnancy	14 days after embryo transfer	Blood test to determine if the embryo transfer was successful or not

Countries

Canada

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026