Infertility
Conditions
Keywords
serum progesterone, embryo transfer, pregnancy rate
Brief summary
Serum progesterone levels prepare the endometrium for implantation and play an important role during embryo transfer (ET). In clinical practice, luteal phase support progesterone supplementation is systematically offered to all women undergoing medically assisted procreation (AMP), independently of ET conditions (fresh and frozen). The investigators propose to perform a prospective cross-sectional single-center cohort study to measure progesterone levels on the day of the ET on all AMP cycles and to compare these levels between active pregnancies and ET unsuccessful cycles. They will determine progesterone threshold levels corresponding to successful attempts in all ET strategies (fresh and frozen) as well as clinical and biological risk factors leading to luteal phase deficiency during ET. They could therefore individualize progesterone supplementation according to patient's needs.
Interventions
OTHERserum progesterone measurement
progesterone levels measurement on the day of the embryo transfer on all AMP cycles
Sponsors
Hospital St. Joseph, Marseille, France
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age ≥ 18 years * planned embryo transfer * signed informed consent
Exclusion criteria
* patients falsely included, major inclusion criteria not respected * lack of social insurance * refusal to participate in the research
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Serum progesterone levels on the day of embryo transfer | During the procedure | µg/L |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| pregnancy rate | 1 month after procedure | Post-embryo transfer βHCG levels (UI/l). |
Countries
France
Outcome results
None listed