Hypertension, Obesity
Conditions
Keywords
NPY
Brief summary
The purpose of this study is to understand how the nervous system communicates to blood vessels to increase blood pressure during stress. The study will also investigate how hypertension and obesity influence the nervous system and vascular function. The study will involve measuring sympathetic nervous system activity and blood flow during common laboratory physiological stress protocols (e.g. hypoxia, exercise), and in response to infusion of drugs that cause vasodilation or vasoconstriction.
Interventions
DRUGNeuropeptide Y
intra-arterial infusion of neuropeptide Y
Sponsors
University of Texas Southwestern Medical Center
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* Control - BMI\<30, age 18-55 * Hypertensive - BMI\<30, age 18-55, diagnosis of hypertension by 24-hour ambulatory blood pressure monitoring Obese- BMI\>30, age 18-55 Obese-hypertensive- BMI\>30, age 18-55, diagnosis of hypertension by 24-hour ambulatory blood pressure monitoring
Exclusion criteria
All groups - presence of other significant cardiovascular disease, renal disease, history of smoking, diabetes,
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood flow measured by doppler ultrasound | Acutely on the day of study | brachial and femoral artery blood flow |
| Muscle sympathetic nervous system activity | Acutely on the day of study | recording of sympathetic nervous system activity from the peroneal or radial nerve |
Countries
United States
Contacts
Primary ContactChristopher M Hearon, Ph.D.
Backup ContactMary Childers
Outcome results
None listed