IVF, Polycystic Ovary Syndrome
Conditions
Brief summary
This study intends to collect about 150 cases of follicular fluid samples from PCOS and non-PCOS infertility patients undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) cycles (in clinical routines).We tend to detect Raman metabolic profile of the follicular fluid of the PCOS and non-PCOS groups, and find the correlation between the metabolic profile of the follicular fluid of PCOS patients and the oocyte quality, IVF outcome and subsequent embryo development are also under investigation. Metabolomics analysis was applied to look for markers of follicular fluid in PCOS patients, and further exploring data and strategies to improve the embryonic development potential and IVF outcome of PCOS patients.
Interventions
DIAGNOSTIC_TESTRaman spectrum
The wavelength of the follicular fluids were scaned by Raman spectrum
Sponsors
ShangHai Ji Ai Genetics & IVF Institute
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SCREENING
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
Yes
Inclusion criteria
* Patients fit the Rotterdam criteria for PCOS * Patients under IVF cycles
Exclusion criteria
* Patients with male factors infertility * Patients with fallopian tube factors infertility
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Difference between polycystic ovary syndrome and normal follicular fluids | 24 months | Raman spectrum was applied and the Raman spectrum characteristic absorption peak can be revealed. PCA analysis was used to measure the degree of differential shifts. |
Countries
China
Outcome results
None listed