Covid19, Critical Illness, Deep Vein Thrombosis, Heart Failure, Myocardial Infarction, Pulmonary Embolism, Renal Failure, Stroke
Conditions
Brief summary
This retrospective cohort study aims to characterise outcomes for patients treated on an intensive care unit (ICU) with COVID-19 in England and Wales, one year after discharge from hospital. Outcomes will be compared with patients admitted as an emergency to an ICU for other conditions. The study will use existing national audit data linked to routine healthcare datasets.
Detailed description
Across England and Wales, over 10,000 patients have been treated for severe coronavirus disease 2019 (COVID-19) on an intensive care unit. Around 60% survived to leave hospital. It is unknown how survivors' severe COVID-19 infection, or the treatment they received on the intensive care unit, will affect their long-term health. Understanding what happens to these patients can help ensure they receive suitable care from their General Practitioner (GP) and other National Health Service (NHS) services after they leave hospital. This study will follow up survivors for 1 year after discharge from hospital. The investigators will use data collected by the Intensive Care National Audit and Research Centre (ICNARC) to identify patients who were treated on an ICU for COVID-19. The investigators will then use NHS data to see whether these patients were readmitted to hospital and why. Information from the Office of National Statistics will identify whether patients died. By linking different sources of patient data, the investigators will estimate the health risks faced by survivors of severe COVID-19. These risks will be compared to those in patients treated on an ICU for other conditions.
Interventions
Not applicable as observational study.
Sponsors
Intensive Care National Audit & Research Centre
University of Oxford
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
16 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age 16 years or over * Admitted to an adult, general ICU in England or Wales as an emergency (unplanned) * Admitted to ICU for either: a) confirmed COVID-19 between 1st January to 1st July 2020 or b) without confirmed COVID-19 between 1st July 2016 and 1st July 2020-
Exclusion criteria
* Patients who died in hospital after treatment on an ICU
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mortality Rate | One year | Mortality after discharge from hospital |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Rate of emergency hospital admission | one year | Emergency hospital admission |
| Rate of emergency hospital admission for respiratory infection | one year | Emergency hospital admission for respiratory infection |
| Rate of emergency hospital admission for a major adverse cardiac event | one year | Emergency hospital admission for a major adverse cardiac event (myocardial infarction, stroke, heart failure) |
| Rate of emergency hospital admission for a venous thrombotic event | one year | Emergency hospital admission for a venous thrombotic event (deep vein thrombosis or pulmonary embolism) |
| Rate of development of end stage renal failure | one year | Development of end stage renal failure treated by renal replacement therapy |
Countries
United Kingdom
Outcome results
None listed