Ventricular Tachycardia
Conditions
Brief summary
This study is being done to determine whether there is an increase in sympathetic nerve activity before the onset of ventricular arrhythmias or irregular heartbeat rhythm. In addition, this study is looking at the relationship between sympathetic nerve activity and how patients with ventricular arrhythmias respond to catheter ablation treatment.
Interventions
None listed
Sponsors
Cedars-Sinai Medical Center
Mayo Clinic
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients who have non-sustained or sustained VA (VA ≥ 30s or receiving appropriate ICD therapies) are presented to the clinic or admitted to the hospital within 7 days of episodes. * The causes of VA are associated with structural heart diseases including ischemic or nonischemic cardiomyopathy (idiopathic cardiomyopathy, hypertrophic cardiomyopathy, cardiac sarcoidosis or amyloidosis, and arrhythmogentic right ventricular dysplasia). * Subjects are 18 years of age and older.
Exclusion criteria
* Female patients who is pregnant or of childbearing potential and not on a reliable form of birth control. * Allergic to skin patch electrodes. * Vulnerable populations (fetuses, neonates, pregnant women, prisoners, institutionalized individuals).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in amplitude of skin sympathetic nerve activity | Baseline, 24 hours post catheter ablation and approximately 3-6 months post-operative | measured in µV |
| Change in LF/HF ratio | Baseline, 24 hours post catheter ablation and approximately 3-6 months post-operative | low frequency (LF)/high frequency (HF) ratio of the skin sympathetic nerve activity |
Countries
United States
Outcome results
None listed