Chronic Consumption of Cannabis
Conditions
Brief summary
The Cannabinoide Hyperemesis Syndrom (CHS) is defined as a recurrent syndrome of intractable vomiting that occurs in chronic cannabis consumers. The diagnosis is linked to clinical criteria only. The physiopathology of CHS is unknown and we observe an increase of cases with this syndrom since 2016 (Schreck et al., 2018). The aim of this study is to investigate the involvement of exogenous cannabinoids concentrations in chronic cannabis users in the occurrence of CHS.
Interventions
PROCEDURE1 blood sample
2 groups of subjects (group 1 : with diagnosis of CHS - group 2 : no diagnosis of CHS) will have 2 blood and 1 urine samples + 1 questionnaire
Sponsors
Poitiers University Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Subjects without protection by a legal regime (guardianship, trusteeship) * Subjects affiliated to an appropriate social security system * Subjects must sign an informed consent form Inclusion Criteria for Group 1: \- Subjects must have the CHS diagnosis confirmed Inclusion Criteria for Group 2: \- Subjects must be chronic cannabis consumers and never had CHS
Exclusion criteria
* Subjects must not have addictive comorbidities or psychoactive substance abuse (except alcohol and tabacco)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| involvement of exogenous cannabinoids concentrations in chronic cannabis users in the occurrence of CHS (see details below for exogenous cannabinoids) | on the day of subjects inclusion | blood and urine concentration, unit of measure ng/mL |
| THC (Tetrahydrocannabinol) | on the day of subjects inclusion | blood and urine concentration, unit of measure ng/mL |
| metabolite of THC : THC-OH (11-hydroxy-Δ⁹-tétrahydrocannabinol) | on the day of subjects inclusion | blood and urine concentration, unit of measure ng/mL |
| metabolite of THC : THC-COOH (11-nor-9-carboxy-Δ⁹-tétrahydrocannabinol) | on the day of subjects inclusion | blood and urine concentration, unit of measure ng/mL |
| CBD (Cannabidiol) | on the day of subjects inclusion | blood and urine concentration, unit of measure ng/mL |
| CBN (Cannabinol) | on the day of subjects inclusion | blood and urine concentration, unit of measure ng/mL |
| CBG (Cannabigerol) | on the day of subjects inclusion | blood and urine concentration, unit of measure ng/mL |
Countries
France
Outcome results
None listed