Periodontitis
Conditions
Brief summary
the aim of our study is to enhance the dissolution and subsequently the local penetration of the drug through the sulcus in addition to controlling the drug release so that, the drug could be potentially absorbed.
Detailed description
Patients will be divided randomly into three groups: Group (I);will be treated with subgingival debridement and subgengival injection of chitosan 2% gel containing a microsponges formulated (SV), Group (II); will be treated with subgingival debridement and subgingival injection of chitosan 2% gel containing free (SV) and Group (III); will be treated by subgingival debridement and placebo gel injected subgingivally. Pocket depth and clinical attachment loss bone gain were recorded preoperative and six months postoperative for all groups.
Interventions
PROCEDUREopen flap subgingival debridement
After the reevaluation phase after that corrective surgical phase started for the three groups. Local infiltration anesthesia administrated then sulcular flaps raised for the purpose of open flap subgingival debridement.Randomization was then performed and concealment from the assessors.
PROCEDURESubgingival injection of chitosan 2% gel
Group (I); injected subgingivally with chitosan 2% gel containing a microsponges formulated drug weekly
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
30 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* patients with chronic periodontitis with minimum two sites of pocket depth \> 5 mm * patients with normal lipid profile * nonsmokers * patients free from any systemic disorders * committed patients to complete the treatment with follow-ups.
Exclusion criteria
* patients with hyperlipidemia * patients taking lipid lowering drugs * smokers * pregnant * Lactating women women, patients with mental or psychological illness and medically compromised patients.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pocket depth | Before the beginning of study | Will be measured in millimetre |
| Clinical attachment loss | Before beginning of the study | Will be measured in millimetre |
Countries
Egypt
Outcome results
None listed