Work of Breathing Under Extreme Hypercapnia Induced by Ventilation Insufficiency

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04835545

Enrollment

Registered

2021-04-08

Start date

2021-03-29

Completion date

2024-04-01

Last updated

2022-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Accident Caused by Snow Avalanche

Keywords

snow, avalanche, hypercapnia, work of breathing

Brief summary

The aim of the study is to investigate Work of Breathing of a person in simulated avalanche snow and consequent use of the measured data for judging which one of three simulated scenarios are alike while increasing hypercapnia in the simulated avalanche snow.

Detailed description

The study is a part of a university diploma thesis aimed at studying physiological conditions and development of breathing parameters of a person breathing in the simulated avalanche snow. The Investigator is measuring Work of Breathing in three scenarios: a) 2L air pocket, b) 2L air pocket with resistance compensation and c) no air pocket. The investigator hypothesize that the Work of Breathing during compensation of air pocket will be alike with no air pocket scenario, thus proving significance of the resistance reduction for survival. The aim of the study is to investigate the effect of Work of Breathing on gas exchange in subjects breathing into the simulated avalanche snow scenarios.

Interventions

OTHERextreme hypercapnia induced by ventilation insufficiency

extreme hypercapnia

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 30 Years

Healthy volunteers

Yes

Inclusion criteria

* healthy and fit volunteers, classified as The American Society of Anesthesiologists class I * without a smoking history

Exclusion criteria

* Tiffeneau Index less than 0.70 * any cardiovascular or respiratory condition

Design outcomes

Primary

Measure	Time frame	Description
The length of breathing	Continuously within up to 7 minute interval from the beginning of the breathing experiment	Time to termination of the breathing experiment due to the decision of the tested subject, or determined by high end-tidal carbon dioxide value or by the order by the clinician assessing the health status of the subjects.

Countries

Czechia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026