Efficacy of Topical Antioxidants in Tretment of Photoaging

Efficacy of a Combination of Topical Antioxidants in Tretment of Photoaged Skin:A Randomized Controlled Trial

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04835259

Enrollment

Registered

2021-04-08

Start date

2021-04-30

Completion date

2022-06-30

Last updated

2021-04-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Photoaging

Keywords

topical antioxidants, photoaged skin

Brief summary

This randomized controlled trial study aims at investigating the efficacy and safety of topical antioxidants in treatment of a cohort of non-elderly volunteers with photoaged skin.

Detailed description

•Sample size calculation: The sample size was assessed prospectively using Openepi version 3.01 to provide a 80% power to detect a 40-50% difference before and after treatment using either topical antioxidants or retinoids with a significance level of 0.05 (based on the results of a previous clinical trial). Assuming 10% dropout, 30 patients will be recruited in each treatment group. •Statistical analysis: Data will be collected and recorded on excel data sheet. Data will be tested for normality. Quantitative data will be represented as mean and standard deviation, or median and interquartile range. Qualitative data will be presented as number and percentage. The relevant statistical method will be used for comparison. P value will be considered statistically significant if it is less than 0.05

Interventions

DRUGSelenium Amino Acid Chelate (Selenium ACE cream)

application of a topical agent over the whole face for 6 months

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

30 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* Adult volunteers \< 50 years old * Clinical and dermoscopic features of photoaging.

Exclusion criteria

* Genodermatoses associated with photosensitivity. * Treatment by medications affecting skin aging (eg, topical and systemic retinoids) in the last 6 months prior to enrollment. * Any recent cosmetic procedures.

Design outcomes

Primary

Measure	Time frame	Description
change in Dermoscopy photoaging scale	assesed every month for 6 months	Dermoscopy photoaging scale (DPAS) is a reliable and valid diagnostic tool that can evaluate photoaged skin quantitatively by the help of objective criteria. It can be used to evaluate the effect of preventive and therapeutic applications for skin aging.

Contacts

Primary Contactesraa ismail

esraasalah123@yahoo.com00201000509636

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026