Comparison of Post-Operative Analgesia After Percutaneous Nephrolithotomy.

Comparison of Post-Operative Analgesia With Peri Tract Local Anesthesia Infiltration and Oral Analgesia Versus Post-Operative Intravenous Analgesia After Percutaneous Nephrolithotomy.

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04835116

Enrollment

Registered

2021-04-08

Start date

2019-04-11

Completion date

2019-10-11

Last updated

2021-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain, Postoperative Pain

Keywords

Local anesthesia, Percutaneous nephrolithotomy.

Brief summary

The rationale of this study was to compare the efficacy of peri-tract bupivacaine infiltration with intravenous post-operative analgesia following PCNL in reference to the context with the previous studies so that we can adopt the better technique to curtail the post-operative pain.

Detailed description

The rationale of this study was to compare the efficacy of peri-tract bupivacaine infiltration with intravenous postoperative analgesia following PCNL in reference to the context with the previous studies so that we can adopt the better technique to curtail the post-operative pain.

Interventions

DRUGBupivacaine Hydrochloride 0.25% Injection. Paracetamol 650mg. Orphenadrine 50mg.

Group A patients were administered per-operative peri tract local anesthesia infiltration with 0.25% bupivacaine augmented by post-operative oral analgesia with a combination of Paracetamol 650 mg and Orphenadrine 50mg 6 hourly.

DRUGparacetamol 1000mg. Tramadol 50mg. Dimenhydrinate 50mg.

Group B patients were only given post-operative intra-venous analgesia by Paracetamol 1gm intravenous 8 hourly augmented with a combination of Tramadol 50mg and Dimenhydrinate 50mg as and when required

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

12 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* all patients undergoing PCNL * age from 12-65 years * normal renal functions * no history of chronic pain * ASA I, II & III * Both genders

Exclusion criteria

* history of local anaesthesia allergy * Redo PCNL * Multiple punctures during PCNL * Excessive intra-operative bleeding * Diabetes mellitus * Coagulopathy * Mental disorder * ASA IV & V * Active urinary tract infection.

Design outcomes

Primary

Measure	Time frame	Description
Comparison of Post-Operative Analgesia With Peri Tract Local Anesthesia Infiltration and Oral Analgesia Versus Post-Operative Intravenous Analgesia After Percutaneous Nephrolithotomy.	6 months	Efficacy of peri-tract infiltration of bupivacaine over standard oral analgesia in patients undergoing PCNL. Measurement: Postoperative pain Measurement tool: Visual analog scale

Countries

Pakistan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026