COVID-19
Conditions
Keywords
COVID-19, Proton pump inhibitor, H2 receptor antagonist
Brief summary
This retrospective cohort study aims to evaluate the effect of proton pump inhibitor (PPI) or histamine-2 receptor antagonist (H2RA) on the clinical outcomes and positivity rates of Coronavirus Disease-19 (COVID-19).
Detailed description
Previous researches on the association between the use of PPI and H2RA and the treatment and prevention of COVID-19 have reported inconsistent findings. This study aimed to evaluate the effect of H2 receptor antagonists and proton pump inhibitors on the clinical outcomes and positivity rates of COVID-19 using the Korean National Health Insurance (NHI) data. This is a retrospective cohort study using the NHI COVID-19 dataset, which includes health insurance data of individuals who underwent COVID-19 PCR test in South Korea. This study aims to evaluate the effect of the use of PPI and H2RA on the positivity rates and clinical outcomes of COVID-19.
Interventions
History of PPI and H2RA prescription of the participants who were tested for COVID-19 will be reviewed.
Sponsors
Dong-A ST Co., Ltd.
Seoul National University Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Individuals who were tested for COVID-19 using real-time reverse transcriptase PCR assay of nasal and pharyngeal swabs
Exclusion criteria
* Record of a new prescription of non-steroidal anti-inflammatory drugs (NSAID) within 1 month of the test date * Patients who died within 48 hours after test.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| COVID-19 test positivity | Through test completion, an average of 1 day | Test positivity rates for COVID-19 nasopharyngeal polymerase chain reaction (PCR): number of participants diagnosed with COVID-19 compared to the number participants who were tested for COVID-19 |
| Mortality | 60 days | Mortality of participants who died after diagnosis of COVID-19 (during the hospitalization or after discharge) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Intensive care unit admission rate | 60 days | Intensive care unit admission rate of patients who were diagnosed with COVID-19 |
| Mechanical ventilator application rate | 60 days | Mechanical ventilator application rate of patients who were diagnosed with COVID-19 |
| Oxygen apply rate (Nasal prong, Facial Mask, High flow nasal cannula) | 60 days | Oxygen apply (Nasal prong, Facial Mask, High flow nasal cannula) rates of patients who were diagnosed with COVID-19 |
| Rates of vasopressor and inotrope use | 60 days | Rates of vasopressor and inotrope use of patients who were diagnosed with COVID-19 |
Countries
South Korea
Outcome results
None listed