Postoperative Pain
Conditions
Brief summary
The aim of this study is to determine the minimal effective ropivacaine concentration required to provide adequate analgesic femoral nerve block in 90% of patients (MEAC90)
Detailed description
* Before induction of GA, all patients will receive sciatic, obturator, lateral femoral cutaneous and femoral nerve blocks. * The femoral nerve block will be performed using 15ml of ropivacaine which concentration relied on the response of the previous patient. * Based on biased-coin design up-down sequential method: when a patient has a negative response, the next patient will receive a concentration 0.01% w/v higher. However if he has a positive response, the next patient will be randomized to receive either the same ropivacaine concentration or a concentration 0.01% w/v less. * Patients with pain free recovery will be considered to have positive response. * Patients' responses will be analyzed to calculate the MEAC90
Interventions
DRUGRopivacaine
all patients will receive femoral nerve block using same volume of ropivacaine but in different concentrations
Sponsors
Healthpoint Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients, who are scheduled for knee ligament reconstruction
Exclusion criteria
* \<18 y, * ASA physical class greater \>III * BMI \>40 has any contraindication for medications or techniques used in the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| effective analgesic femoral nerve block | in recovery unit (one hour after surgery) | postoperative pain. it will be assessed using numerical rating scale (NRS). NRS, 0 = no pain; 10 = worst pain imaginable; if NRS ≥ 3, pain (ineffective block) is considered, other wise a successful block will be considered. |
Countries
United Arab Emirates
Outcome results
None listed