Peri-Implantitis
Conditions
Keywords
photodynamic therapy*, periimplantitis*, diabetes mellitus*, indocyanine green*, photosensitizer*
Brief summary
In this study, the effect of photodynamic therapy (indocyanine green mediated) on the clinical, biological and inflammatory aspects was assessed in diabetic patients having peri-implantitis
Interventions
BIOLOGICALICG-PDT
An 810 nm diode laser (A.R.C. laser GmbH, Nurnberg, Germany) with a power of 200 mW (continuous mode) and total energy of 4 J was used to excite the ICG by starting from the papilla for 30 s followed by the insertion inside the peri-implant pocket depth for 10 s from both buccal and lingual side moving to coronal direction. The treatment was applied according to the manufacturer's recommendation. The PDT was performed by a single operator in all test patients
DEVICEperi-implant mechanical debridement
The peri-implant mechanical debridement was done with the help of ultrasonic carbon tip (Vector, Durr Dental, Bietigheim-Bissingen, Germany).
Sponsors
King Saud University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
45 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Inclusion Criteria: * adult patients above 45 years of age having type 2 DM * HbA1c (≥6.5%) and fasting glucose test * probing depth ≥6 mm with bleeding and/or suppuration on at least one site around dental implants that remained in situ * On radiographic assessment, the implants exhibited ≥ 3 mm alveolar bone loss apical to the coronal region of the intraosteal portion of the dental implant. *
Exclusion criteria
Patients were excluded if they indicated current or former history of tobacco smoking, any systemic disease other than DM, enrolled in a non-surgical periodontal maintenance program, history of implant repair, pregnancy, and part six months use of antimicrobials, non-steroidal anti-inflammatory drugs, bisphosphonates, or corticosteroids.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Suppuration | 6 months | Presence or absence of pus |
| Crestal bone loss | 6 months | Measurement of consecutive millimeter markings of the alveolar bone levels |
| Bleeding on probing | 6 months | Presence or absence of bleeding indicated as '1' or '0', respectively |
| Plaque index | 6 months | Presence or absence of plaque indicated as '1' or '0', respectively. |
| Probing depth | 6 months | Measurement of consecutive millimeter markings of the periodontal pocket depth |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Microbiological analysis (Porphyromonas gingivalis) | 6 months | Bacterial viability from the peri-implant plaque |
| Microbiological analysis (Treponema denticola) | 6 months | Bacterial viability from the peri-implant plaque |
| HbA1c | 6 months | Assessment of serum HbA1c |
| Interleukin-1 beta | 6 months | Assessment from peri-implant crevicular fluid |
| Interleukin-6 | 6 months | Assessment from peri-implant crevicular fluid |
Countries
Saudi Arabia
Outcome results
None listed