Insulin
Conditions
Brief summary
Insulin intensive therapy have traditionally been considered a sequential therapy in type 2 diabetes last choice, a number of guidelines and consensus recommendations insulin intensive therapy can be as obvious hyperglycemia in patients with newly diagnosed T2DM part of a line, a subset of patients after insulin intensive treatment target often need to change to other treatments, especially for senile diabetes patients, due to its self management ability, simplify the insulin solution is more urgent. Current clinical guidelines do not provide specific clinical guidance, such as the timing and method of switch after initial insulin intensive therapy. The purpose of this study was to explore the timing, suitable population and conversion methods of insulin regimens after treatment.
Detailed description
Selecting initial insulin intensive therapy during the period of hospitalization in patients with type 2 diabetes, collect the basic information and biochemical information collection, including gender, age, duration of diabetes, intensive glucose-lowering treatment plan before treatment, diabetes complications, merger disease, smoking, drinking, height, weight, blood pressure, fasting glucose, glycosylated hemoglobin and glycosylated serum protein, insulin, c-peptide, liver and kidney function, blood lipid, blood routine, hypoglycemia is happening almost 1 month. Follow-up was conducted in January, March and June. Endocrinologists decide whether to continue the original hypoglycemic regimen or adjust it according to the glycemic control goals, islet β-cell function, diabetes complications, complications, hypoglycemia and other combination drugs, as well as patients' treatment willingness and compliance. To compare the timing of conversion of treatment regimens, the proportion of conversion to each regimen and the situation of reaching the standard, and to further analyze and compare the characteristics of people who switched to different regimens, in order to establish the basis for the selection of adjustment regimens after insulin treatment.
Interventions
DRUGContinuous intensive insulin therapy
After initial intensive insulin therapy in hospital, patients were grouped according to different treatment regimens within 6 months of discharge
Sponsors
Shanghai Zhongshan Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with type 2 diabetes; * Patients who started intensive insulin therapy during hospitalization * Age ≥18 years old
Exclusion criteria
* Type 1 diabetes, special type diabetes * Acute complications of diabetes (diabetic ketoacidosis, hyperglycemia and hyperosmolarity) * Severe infection * pregnancy or planned pregnancy * Participating in other clinical studies or trials
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in HbA1c | 1，3，6 months | HbA1c in different conversion regimens |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The average blood glucose | 1，3，6 months | The average blood glucose in different conversion regimens |
| Fasting blood glucose | 1，3，6 months | Fasting blood glucose in different conversion regimens |
| Postprandial blood glucose | 1，3，6 months | Postprandial blood glucose in different conversion regimens |
| Incidence of hypoglycemia | 1，3，6 months | Incidence of hypoglycemia in different conversion regimens |
| Impact on body weight | 1，3，6 months | Impact on body weight in different conversion regimens |
Countries
China
Contacts
Primary ContactXiao ying Li, MD
Backup ContactYing Chen, MD
Outcome results
None listed