Traumatic Brain Injury
Conditions
Brief summary
evaluation of the effect of Propranolol versus propranolol and clonidine on decreasing sympathetic hyperactivity after moderate traumatic brain injury
Detailed description
measuring catecholamine levels after moderate traumatic brain injury after giving propranolol and clonidine
Interventions
DRUGPropranolol
Test of catecholamines level in moderate traumatic brain injury
Sponsors
Minia University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* GCS on admission between 9 and 12 age 18 up to 60 years both sexes
Exclusion criteria
* history of heart disease, cardiac arrhythmia and myocardial infarction diagnosis ofpreexisting brain dysfunction. impending brain herniation and craniotomy diagnosis of spinal cord injuries. diagnisis of severe liver and renal disease current use of beta blocker and or alpha agonist current using of intravenous vasopressor contraindication to enteral feeding and can not swallow pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| catecholamine level on day 7 | seven days | measuring catecholamine level on day 7 after giving study drugs |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| mean arterial blood pressure every 4 hours herat rate every 4 hours temperature every 4 hours respiratory rate every 4 hours | 7 days | measuring hemodynamics every 4 hours |
| Glascow coma scale | 7 days | measuring glascow coma scale twice daily between 9 and 12 and higher score means better outcome. |
Countries
Egypt
Outcome results
None listed