Hypertension
Conditions
Keywords
Blood Pressure monitoring, Primary care, Physical exercises, Training intensity
Brief summary
Single-center, randomized, parallel-group, controlled, open-label study. The aim of the study was to evaluate the effects of an exercise training program intervention of different intensities (high intensity versus low-moderate intensity) on blood pressure reduction as a complementary strategy in hypertensive individuals being treated with at least one antihypertensive drug.
Detailed description
All participants included in the study were referred by their primary care physicians, who prescribed physical exercise as a healthy lifestyle intervention added to the antihypertensive regimens in the framework of the ACTIVA-Murcia Program. Participants in the HIT and LMIT groups followed the same physical training program, with the only difference being the intensity of the training. The program included two phases of physical exercise lasting 12 weeks and 16 weeks, respectively, separated by a 7-week rest period, which coincided with a holiday period. The times of both phases were not equal in terms of duration, since it is a community physical exercise program established by the Region of Murcia, and does not depend on the researchers. The program was developed by graduates in Physical Activity and Sport Sciences, who were in charge of teaching the exercises and supervised each training session. Participants assigned to the HIT and LMIT groups were given guidelines to continue physical exercise during the 7-week rest period, while participants in the control group were offered to participate in the program after the study.
Interventions
The physical training program was carried out 3 days a week in 1-hour sessions focused on basic endurance exercises (global body activities), strength (specific muscle region activities) and flexibility. Intensity was be determined by Maximum Heart Rate (HRF).
OTHERNo physical exercise
No programmed physical exercise
Sponsors
Universidad Católica San Antonio de Murcia
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
A single-center, randomized, parallel-group, controlled, and open-label study was conducted.
Eligibility
Sex/Gender
ALL
Age
40 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Age between 40 and 65 years. * Under treatment with at least one antihypertensive drug for hypertension. Treatment should have lasted at least 12 months prior to inclusion in the study. * Diagnosed with dyslipidemia under pharmacological treatment or with a specific hypercholesterolemia (\> 200 mg/dL) in the past and a cholesterol level at the start of the study greater than 200 mg/dL. * Patient in Primary Prevention. * Subjects who do not develop physical exercise scheduled on a weekly basis. * Subjects who have given written informed consent to participate in the study.
Exclusion criteria
* Serious or terminal illnesses. * Diagnosis of ischemic and/or cerebrovascular heart disease. * Presence of chronic diseases that prevent the performance of a physical exercise program or a stress test (disabling arthropathies, chronic moderate/severe pneumopathies, arrhythmias, etc). * Severe mental illnesses: psychosis, severe depressive disorder, neurosis. * Diabetes mellitus. * Presence of absolute or relative contraindications dictated by the American College of Sports Medicine (ACSM, 1995), during the performance of the stress tests. * Pregnant or breast-feeding women * Inability to understand the informed consent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Ambulatory blood pressure monitoring | Measurements will be taken at baseline and 12 weeks (phase 1) and at baseline and 16 weeks (phase 2) | Blood pressure is measured with a holter |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Diastolic blood pressure | Measurements will be taken at baseline and 12 weeks (phase 1) and at baseline and 16 weeks (phase 2) | Blood pressure is measured with a holter |
| Mean blood pressure | Measurements will be taken at baseline and 12 weeks (phase 1) and at baseline and 16 weeks (phase 2) | Blood pressure is measured with a holter |
| Pulse pressure | Measurements will be taken at baseline and 12 weeks (phase 1) and at baseline and 16 weeks (phase 2) | Blood pressure is measured with a holter |
| Lipid profile | Measurements will be taken at baseline and 12 weeks (phase 1) and at baseline and 16 weeks (phase 2) | Blood samples |
| Antihypertensive medication | Measurements will be taken at baseline and 12 weeks (phase 1) and at baseline and 16 weeks (phase 2) | Record of medication and dosage |
| Systolic blood pressure | Measurements will be taken at baseline and 12 weeks (phase 1) and at baseline and 16 weeks (phase 2) | Blood pressure is measured with a holter |
| Control of dietary intake | A nutritional registry will be carried out. The nutritional intake of three days in two periods will be collected. One record at the beginning and another at the end, that is, six days. | Diet source |
| Muscle function | Measurements will be taken at baseline and 12 weeks (phase 1) and at baseline and 16 weeks (phase 2) | Isokinetic dynamometry. |
| Balance | Measurements will be taken at baseline and 12 weeks (phase 1) and at baseline and 16 weeks (phase 2) | Force platform Kistler |
| Aerobic function | Measurements will be taken at baseline and 12 weeks (phase 1) and at baseline and 16 weeks (phase 2) | Modified Balke-Ware protocol on a rolling mat |
| Framingham tables by category | Measurements will be taken at baseline and 12 weeks (phase 1) and at baseline and 16 weeks (phase 2) | Physicians Global Assessment to measure cardiovascular risk |
| Lipid lowering medication | Measurements will be taken at baseline and 12 weeks (phase 1) and at baseline and 16 weeks (phase 2) | Record of medication and dosage |
Countries
Spain
Outcome results
None listed