Endometriosis
Conditions
Brief summary
Endometriosis is an inflammatory condition that is often treated by surgery. MRI and ultrasound are used for the preoperative morphological assessment. Currently, only surgery allows the exhaustive and qualitative diagnosis of lesions. The PET scan, fixing in certain inflammatory pathologies and in certain cases of endometriosis, could refine this assessment by evaluating the location of the lesions.
Interventions
DRUGPET scanner with injection of 18 FDG (18F-2-fluoro-2-deoxy-D-glucose) (radiolabel)
A PET scan will be performed in the patients included, in addition to the conventional imaging workup (MRI, endovaginal and pelvic ultrasound).
Sponsors
Centre Hospitalier Universitaire de la Réunion
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* Patient aged over 18 and under 50 * Patient with symptomatic endometriosis with indication for surgery * Showing at least one typical endometriosis lesion on MRI, greater than 5mm * Accepting surgical management * Having signed an informed consent after information * Affiliate or beneficiary of a social security scheme
Exclusion criteria
* Patient who has received an injection with GnRH (gonadotropin-releasing hormone ) analogues for less than 3 months (because it induces the quiescence of the disease which is no longer stimulated by estrogen secretion) * Patient with a history of heavy abdominopelvic surgery * Diabetic patient * Patient unable to understand the interest of the study * Patient already included in another therapeutic trial with an experimental molecule. * Persons referred to in articles L1121-5 to L1121-8 of the PHC (public health code) (corresponding to all protected persons: pregnant woman, parturient, nursing mother, person deprived of liberty by judicial or administrative decision, minor, and person making the subject to a legal protection measure: guardianship or curators) * Contraindications to PET Scanner (major claustrophobia, contraindication or hypersensitivity to 18-FDG or one of its excipients, contraindication or hypersensitivity to Ultravist® or one of its excipients, etc.) * Contraindication to surgery or anesthesia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| To assess the PET scan in the diagnosis of endometriosis lesions compared to surgery in terms of number of lesions diagnosed and locations. | at inclusion (before surgery) | Total number of endometriosis lesions diagnosed by the PET scanner |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Compare the results of the PET scanner and MRI for the sensitivity of detection of endometriosis lesions | up to 14 weeks (after surgery) | number of endometriosis lesions |
| Define a reading threshold of SUV (Standardized Uptake Value) on a PET scanner for the diagnosis of endometriosis | up to 14 weeks (after PET-Scanner) | degree of inflammation of the cells |
Countries
France
Outcome results
None listed