Chronic Kidney Diseases
Conditions
Keywords
Chronic kidney disease on dialysis, Physical exercise, Regional myocardial function, Myocardial stunning
Brief summary
This study aims at evaluating, in chronic kidney disease patients on dialysis, the effect of acute per- or pre-dialytic physical exercise on regional myocardial function and myocardial stunning, blood viscosity, arterial stiffness, variability of sinus rhythm, dialysis efficacy, inflammation, mineral and bone disorders, myokines and cardiac remodeling markers.
Interventions
PROCEDUREDialysis without physical exercise
Hemodialysis control condition
PROCEDUREDialysis with pre-dialytic physical exercise
Patients will pedal for 30 minutes using a ergometer directly attached to the dialysis bed. The exercise will be performed 60 minutes before connection to hemodialysis.
PROCEDUREDialysis with per-dialytic physical exercise
Patients will pedal for 30 minutes using a ergometer directly attached to the dialysis bed. The exercise will start 30 minutes after the start of dialysis.
Sponsors
AIDER- Santé
Avignon University (EA4278 - LaPEC)
Pr Philippe OBERT
Dr Claire MAUFRAIS
University Hospital, Montpellier
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Intervention model description
All patients will be assigned to one dialysis session without physical exercise, one dialysis session with pre-dialytic physical exercise and one dialysis session with per-dialytic physical exercise in random order.
Eligibility
Sex/Gender
ALL
Age
20 Years to 79 Years
Healthy volunteers
No
Inclusion criteria
* Patient aged ≥ 20 to ≤ 79 years * Undernourished patient according to the ARNOS score : ≥ 2 * No medical contraindication to physical activity * Life expectancy greater than 6 months * Patient on hemodialysis for more than 3 months * Patients with relatively good echogenicity
Exclusion criteria
* Patient is participating in another Category I interventional study, or has participated in another interventional study within the past 3 months * The patient is in an exclusion period determined by a previous study * The patient is under legal protection or under guardianship or curatorship * It turns out to be impossible to give the patient informed information, or the patient refuses to sign the consent * Pregnant, parturient or breastfeeding patient * Patient with a contraindication to retraining * Patient with valvular heart disease, arteriopathy of the lower limbs stage III and IV, amputation or knee or hip prosthesis * Patient with musculoskeletal problems * Patient with severe respiratory failure * Paired sleep apnea syndrome * BMI\> 35 * Patient with automatic implantable defibrillator * Heart transplant * Uncontrolled high blood pressure * Ejection fraction \<45% * Unstabilized coronaries * Non-contributory stress ultrasound
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in regional myocardial function and myocardial stunning | Weekly over a period of 3 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Change in arterial stiffness | Weekly over a period of 3 weeks |
| Change in sinus rhythm | Weekly over a period of 3 weeks |
| Change in dialysis efficacy | Weekly over a period of 3 weeks |
| Change in blood viscosity | Weekly over a period of 3 weeks |
| Change in mineral and bone metabolism markers | Weekly over a period of 3 weeks |
| Change in myokines | Weekly over a period of 3 weeks |
| Change in cardiac remodeling markers | Weekly over a period of 3 weeks |
| Change in inflammatory markers | Weekly over a period of 3 weeks |
Countries
France
Contacts
Primary ContactJean Paul CRISTOL, MD, PhD
Outcome results
None listed