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Insulin Sensitivity Response to High-Intensity Training in Insulin Resistance During Pregnancy

Impact of High-Intensity Interval Training on Insulin Resistance During Pregnancy: A Randomized Control Trial.

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT04830995
Enrollment
40
Registered
2021-04-05
Start date
2020-03-24
Completion date
2020-11-01
Last updated
2023-01-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diet, Healthy, High Intensity Interval Training

Keywords

Training, Insulin Resistance, Pregnancy

Brief summary

Insulin Resistance is one of the common complications that occur during pregnancy. Early intervention is essential to prevent the development of the diseaseThere is evidence that physical inactivity increases the risk of a lot of adverse health problems, including coronary heart disease, type 2 diabetes, breast and colon cancers. It also shortens life expectancy. Pregnancy is a period in the life of women that is often associated with decreased daily physical activity and decreased participation in sports and exercise . In the first few weeks of pregnancy, maternal carbohydrate metabolism is affected by a rise in maternal levels of estrogen and progesterone that stimulates pancreatic β-cell hyperplasia and insulin secretion. As pregnancy progress, pancreatic islet cell hypertrophy continues and there is an increased insulin response to glucose or meal stimulation.

Detailed description

This study was carried out upon twenty multigravida pregnant female between 5-6 months gestation with IR calculated by HOMA test (fasting blood glucose× fasting insulin) ÷ 22.5. Fasting blood glucose was assessed by the method approved by (7, 13) .The test materials for this method were supplied as kits by Diamond Diagnostics, while Insulin concentrations were stated in formerly frozen and defrosted serum samples by enzyme immunoassay using the human Insulin ELISA kits.

Interventions

DIETARY_SUPPLEMENTmoderate restricted diet (1800-2000 kcal/day) for four weeks

high intensity interval training 3 sessions for four weeks

Sponsors

Heba mohamed Embaby
CollaboratorUNKNOWN
Salwa Elgendy
CollaboratorUNKNOWN
Cairo University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)

Masking description

Randomization was done by sealed envelope

Intervention model description

group (A) received HIIT and low diet for four weeks, 3 sessions weekly. While the control group received diet only.

Eligibility

Sex/Gender
FEMALE
Age
25 Years to 35 Years
Healthy volunteers
No

Inclusion criteria

* forty multigravida females. * their age ranged between 25 to 35 years old. * Body mass index (BMI) \<30kg/ m².

Exclusion criteria

* females with pelvic pathology as endometriosis. * females have irregular menstrual cycles.

Design outcomes

Primary

MeasureTime frameDescription
Fasting blood glucose levelthree monthsFasting blood glucose level were measured by expert specialist before and after intervention period from 24th to 37th weeks of pregnancy.

Secondary

MeasureTime frameDescription
Fasting Insulin Levelthree monthsFasting blood insulin level were measured by expert specialist before and after intervention period from 24th to 37th weeks of pregnancy.

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026