Motor Recovery, Rehabilitation, Stroke, Transcranial Direct Current Stimulation
Conditions
Brief summary
Patients with chronic stroke (\>6 months after stroke) having unilateral upper limb hemiparesis will be recruited. Patients will maintain their usual inpatient rehabilitation including occupational therapy. At baseline (T0) and after 2weeks of enrollment (T1), Fugl-Meyer assessment (FMA) will be assessed at each time. And patients with the changes of FMA between T0 and T1 less than 3 points will be finally recruited. The enrolled patients will receive additional 30-min cathodal transcranial direct current stimulation (tDCS) over the contralesional motor cortex for 10 consecutive weekdays, with maintaining their usual conventional rehabilitation. At T1 and immediately after 10-seessions of tDCS (T2) and 1 month after completing 10-tDCS session (T3), FMA, Actional Research Arm Test (ARAT), Box and Block Test (BBT) and electroencephalography (EEG) were measured.
Interventions
DEVICECathodal transcranial direct current stimulation (tDCS) over the contralesional motor cortex
Cathodal tDCS will be applied to the contralesional motor cortex with 2mA intesntisy for 30 mins/day. Total 10 sessions will be applied.
Sponsors
Rusk Rehabilitation Hospital
Seoul National University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
19 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* age ranges from 19 to 85 yrs old * stroke patients with unilateral hemiparesis * 1st ever stroke * chronic stroke (\>6 months after stroke)
Exclusion criteria
* recurrent stroke * history of traumatic brain injury * Minimental state examination score is 15 or less. * Unstable medical conditions * Severe delirium, disorders of consciousness * pregnancy * can not attach tDCS electrode on the scalp due to skin conditions * can not maintain the sitting position * intracranial metals
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in Fugl-Meyer Assesment Score 1 | Between T1 (before tDCS) and T2 (immediately after completing 10 sessions of tDCS) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in Action Research Arm Test Score 1 | Between T1 (before tDCS) and T2 (immediately after completing 10 sessions of tDCS) | — |
| Changes in Action Research Arm Test Score 2 | Between T2 (immediately after completing 10 sessions of tDCS) and T3 (1 month after completing 10 sessions of tDCS) | — |
| Changes in Box and Block Test Score 1 | Between T1 (before tDCS) and T2 (immediately after completing 10 sessions of tDCS) | — |
| Changes in Fugl-Meyer Assesment Score 2 | Between T2 (immediately after completing 10 sessions of tDCS) and T3 (1 month after completing 10 sessions of tDCS) | — |
| Changes in EEG index1 | Between T1 (before tDCS) and T2 (immediately after completing 10 sessions of tDCS) | Various kinds of EEG indexe.g., network indexes, event-related dysynchronization, mu suppression) will be surveyed. |
| Changes in EEG index 2 | Between T2 (immediately after completing 10 sessions of tDCS) and T3 (1 month after completing 10 sessions of tDCS) | Various kinds of EEG indexe.g., network indexes, event-related dysynchronization, mu suppression) will be surveyed. |
| Changes in Box and Block Test Score 2 | Between T2 (immediately after completing 10 sessions of tDCS) and T3 (1 month after completing 10 sessions of tDCS) | — |
Countries
South Korea
Contacts
Primary ContactWon-Seok Kim
Outcome results
None listed