Air Pollution, Cognition, Exercise, Health Promotion
Conditions
Brief summary
A double-blind randomized controlled trial design is used in this study. A mixed design of 2 (pollution reduction group vs. no pollution reduction group) × 3 (high intensity intermittent exercise \[HIIT\], moderate intensity of aerobic exercise \[MICT\] and control group \[CONT\]) is used. 93 subjects recruited by advertising will be randomly divided into 6 groups: high intensity exercise group (pollution reduction vs no pollution reduction), moderate intensity aerobic exercise group (pollution reduction vs no pollution reduction) and Stretching group (Control) (pollution reduction vs no pollution reduction).
Detailed description
Environmental intervention program In the pollution reduction groups, the air purification system is used 2 hours before the subjects entered the room to minimize the indoor PM2.5 and PM10. Exercise intervention program including HIIT, MICT and Stretching (Control) group : The VO2max of all subjects are measured one week before the experiment. HIIT program: 20 minutes exercise of HIIT (1min of 100% VO2max and 1min of 50% VO2max alternately) and 10 minutes of warm-up and relaxation. MICT program: 20 minutes exercise of 70-75% VO2max and 10 minutes of warm-up and relaxation. Stretching control group: 30 minutes of stretching, posture adjustment and rehabilitation courses taught by professional therapists.
Interventions
BEHAVIORALExercise
Two types of exercise intervention and control group
BEHAVIORALAir purification
Air purification in order to reduce the PM2.5 and PM10
Sponsors
Tsinghua University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Masking description
Participants and investigators are blinded, and part of the outcome assessors are blinded.
Intervention model description
Double blind randomized controlled trial
Eligibility
Sex/Gender
ALL
Age
20 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* No regular exercise in the past six months; * Healthy people without history of disease; * Aged between 20 and 30 years old.
Exclusion criteria
* Professional athletes; * Regular exercise in the past six months; * People who are injured or have a history of disease in the past six months; * People who have a history of taking medicine in the past six months.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of cognitive function | Before and after acute exercise (about 30 minutes). | Cognitive function measured by computer-based tasks including executive function |
| Change of biomarkers | Before and after acute exercise (about 30 minutes). | The cognitive-related biomarkers including brain derived neurotrophic factor |
| Change of oxyhemoglobin | Before and after acute exercise (about 30 minutes). | Mearsurement of oxyhemoglobin using fNIRS |
| Change of transcriptions | Before and after acute exercise (about 30 minutes). | The molecular response of exercise and environment through the measurement of peripheral blood |
| Change of metabonomics | Before and after acute exercise (about 30 minutes). | The molecular response of exercise and environment through the measurement of peripheral blood |
| Change of cerebral blood flow | Before and after acute exercise (about 30 minutes). | The blood flow of middle cerebral artery measured by ultrasonic doppler |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change of cognitive function | Three months (from baseline to the third month) | Cognitive function measured by computer-based tasks including executive function |
| Change of transcriptions | Three months (from baseline to the third month) | The molecular response of exercise through the measurement of peripheral blood |
| Change of aerobic capacity | Three months (from baseline to the third month) | The aerobic capacity measured by the gas metabolism analyzer |
| Change of cerebral blood flow | Three months (from baseline to the third month) | The blood flow of middle cerebral artery measured by ultrasonic doppler |
| Change of biomarkers | Three months (from baseline to the third month) | The cognitive-related biomarkers including brain derived neurotrophic factor |
| Change of oxyhemoglobin | Three months (from baseline to the third month) | Mearsurement of oxyhemoglobin using functional near infrared spectroscopy |
| Change of metabonomics | Three months (from baseline to the third month) | The molecular response of exercise through the measurement of peripheral blood |
Countries
China
Outcome results
None listed