Chronic Idiopathic Pruritus
Conditions
Brief summary
Chronic idiopathic pruritus (CIP) is a frequent and disabling condition, for which there is no specific treatment. It was shown previously that hypnosis can relieve painful sensations. Pain and pruritus share many similarities regarding sensory receptors and pathways, suggesting that hypnosis might help relief CIP.
Detailed description
Chronic idiopathic pruritus (CIP) is a frequent and disabling condition, with significative impact on quality of life. At present, there is no specific treatment for CIP. Topical steroids are frequently used, with partial efficacy, and adverse effects. Hypnosis is a specific state of conscience. It differs from waking state, sleeping state, relaxation, or meditation. In this state, the person is highly responsive to suggestion. In medicine, hypnosis can be used to engage the internal resources of the person against unpleasant feelings. It was shown previously that hypnosis can relieve painful sensations. Pain and pruritus share many similarities regarding sensory receptors and pathways, suggesting that hypnosis might help relief CIP.
Interventions
OTHERHypnosis
Chronic idiopathic pruritus is treated by hypnosis
Sponsors
Centre Hospitalier Universitaire de Nice
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Male or female of at least 18 years at screening * Diagnosis of chronic (at least 6 wks.) idiopathic pruritus * Pruritus Numeric Rating Scale \> = 4
Exclusion criteria
* Pruritus caused by a dermatological or a systemic conditions * Suicidal crisis, moderate, or severe * Psychosis (schizophrenia, persistent delusional disorder) * Bipolar disorder, not stabilized or decompensating * Personality disorder, decompensated
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change From Baseline in Pruritus Numeric Rating Scale | Day 84 | Assessment of the intensity of pruritis in Pruritus Numeric Rating Scal; the minimum and maximum values 0 to 10 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change From Baseline in Pruritus Verbal Rating Scale | Day 84 | Assessment of Pruritus by pruritus Verbal Rating Scale; the minimum and maximum values 0 to 4 |
| Change From Baseline in Sleeping Scale | Day 84 | assessment in sleeping scale ; the minimum and maximum values 0 to 10 |
| Change From Baseline in DLQI scale | Day 84 | assessment in DLQI scale; result between 0 to 30 |
| Change From Baseline in HAD scale | Day 84 | assessment in HAD scale; result between 0 to 42 |
| Change From Baseline in usage of topical steroids | Day 84 | assessment in usage of topical steroids |
| Evaluation of tolerance of hypnosis | Day 84 | assessment of tolerance of hypnosis with report of adverse event |
Countries
France
Contacts
PRINCIPAL_INVESTIGATORBAHADORAN PHILIPPE
Centre Hospitalier Universitaire de Nice
Outcome results
None listed