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Antioxidant Vitaminas and Hypertrophy Adaptations to Resistance Training

Vitamins C and Vitamin E and Hypertrophy Adaptations to Resistance Traini

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT04828642
Enrollment
30
Registered
2021-04-02
Start date
2021-02-01
Completion date
2021-06-30
Last updated
2021-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertrophy

Brief summary

This investigations aims to investigate whether supplementation with antioxidant vitamins (vitamin C and vitamin E) can influence, enhancing or blocking, the hypertrophic adaptations caused by strength training in sedentary subjects.

Detailed description

A randomized, double-blind, placebo-control controlled trial will be conducted. In a previous session volunteers will be interviewed to determine if they meet the inclusion criteria. Will be done two weeks of flushing out other types of supplementation and strenuous physical exercise, along with familiarization with the strength training program and performance tests to be carried out during the rehearsal. Subsequently, it will be a week without exercising to start with the experimental designs. From the start of the trial, participants should avoid physical exercise. strenuous outside the training protocol and if usual, they will only be able to perform one resistance training session per week. Participants should avoid ingesting of foods that contain high amounts of antioxidant compounds: more than two juices of fruits, more than four cups of coffee or tea. Juices with high antioxidant content should be avoided. Alcoholic beverages should also be avoided. * Group 1 (G1): Antioxidant vitamins (VitC (1000 mg) + VitE (235 mg)) + exercise * Group 2 (G2): Placebo + exercise A supplementation period of 12 weeks will be carried out. In each period, supplementation with antioxidant vitamins: VitC (1000 mg) + VitE (235 mg) or with placebo. All participants will ingest the supplementation between 1-3 hours before training, the days of rest in the mornings. All participants will perform a 12-week strength training protocol. The training session performed in the sharp design will be the first training session in chronic design. Being the baseline (E0) and post-exercise (E1) assessment performed in G1, G2 and G3 also the first evaluation corresponding to the chronic design. In the middle of the supplementation period (week 6) and at the end, two new evaluations (week 12). Baseline evaluations will be performed prior to an exercise session of week 6 (E2) and at the last exercise session (E3) of the following parameters: performance physique, body composition, micronutrient analysis, muscle ultrasound. I also know conduct post-exercise physical performance assessments Figure 2. The strength training protocol will be carried out 4 days a week at the facilities sports of the European University. The sessions will be planned by a professional from the Sciences of Physical Activity and Sports. Sessions will be tracked through a diary.

Interventions

DIETARY_SUPPLEMENTVitamin C and vitamin E

1000 mg 235 mg

DIETARY_SUPPLEMENTPlacebo

Placebo

Sponsors

Universidad Europea de Madrid
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)

Masking description

The provider will produce the supplementation and the placebo with the same aspect, marked with numbers

Intervention model description

A randomized, double-blind, placebo-control, parallel controlled trial will be conducted.

Eligibility

Sex/Gender
MALE
Age
18 Years to 30 Years
Healthy volunteers
Yes

Inclusion criteria

* Experience in strength training of at least one year

Exclusion criteria

* Smokers * Antioxidant supplementation * Injuries or diseases

Design outcomes

Primary

MeasureTime frameDescription
DEXAWeek 0Evaluation of muscle mass with dual energy X-ray absorptiometry
AnthropometryWeek 0Evaluation of muscle mass by a ISAK 1 level anthropometrist
BioimpedanceWeek 0Evaluation of muscle mass with an Inbody
DOMSWeek 0Delayed onset muscle soreness evaluated with visual analoguic scale (0 no pain- 10 maximal pain)
Manual dinamometryWeek 0Handgrip
Leg dinamometryWeek 0Dinamometer
RPEWeek 010-point scale (no exertion 0- maximal effort 10)
1 RMWeek 0Bench press and squats
Parameters determined by ENCODERWeek 0Bench press and squats

Countries

Spain

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026