Liver Cirrhosis
Conditions
Brief summary
Disorders of glucose metabolism, such as impaired glucose intolerance (IGT) and diabetes mellitus (DM), frequently occur in cirrhosis. However, it has been underestimated when fasting plasma glucose (FPG) levels are considered. We aimed to evaluate who needs to be undertaken a 75-g oral glucose tolerance test (OGTT) to find underlying subclinical diabetes.
Interventions
None listed
Sponsors
Yonsei University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Liver cirrhosis * Admitted to a hospital
Exclusion criteria
* Previously confirmed DM * Being treated for DM * Standard risk factors of T2DM, such as high body mass index and family history of diabetes * Symptoms of DM, such as increased thirst and the need to urinate * Either hepatocellular carcinoma or other malignancy * Hepatic failure or uncontrolled decompensation \[that is, refractory ascites or active variceal hemorrhage\] * Significant illnesses such as sepsis that may have interfered with glucose metabolism * Pancreatic dysfunction such as acute/chronic pancreatitis that may have affected glucose metabolism.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Survival | through study completion, an average of 3 year | Overall survival |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| major complications of cirrhosis | through study completion, an average of 3 year | hepatic encephalopathy (HE), the development of spontaneous bacterial peritonitis (SBP), acute kidney injury (AKI), variceal bleeding, and infection |
Outcome results
None listed