Lung Cancer
Conditions
Keywords
Prehabilitation, Physical activity, Lung resection, Functional capacity
Brief summary
This research study is evaluating a prehabiliation intervention designed to improve postoperative functional capacity (measured by 6-minure walking distance) in individuals undergoing lung resection for cancer.
Interventions
BEHAVIORALHealth education control
Participants will: * Receive four recorded health education talks (twice per week for two weeks) * Receive a brief health education booklet on dietary education for chronic lung conditions, preoperative preparation, and postoperative recovery * Receive usual care.
BEHAVIORALPrehabilitation intervention
Participants will: * Receive four supervised exercise classes (twice per week for two weeks) one-to-one by an exercise specialist; * Practice six sessions of home-based exercise (three times per week for two weeks); * Practice unsupervised respiratory muscle training at home (twice daily for two weeks); * Receive usual care.
Sponsors
The University of Hong Kong
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
45 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. Patients who are diagnosed of stage I, II, or IIIA Non-small-cell lung carcinoma (NSCLC) diagnosis, with or without pre-operative histologic confirmation 2. Patients scheduled to undergo lung resection surgery at least two weeks from recruitment 3. Patients with a Eastern Cooperative Oncology Group (ECOG) score of 0 or 1 at recruitment 4. Patients with no evidence of recurrent or progressive disease 5. Patients aged 45-80 years 6. Patients able to communicate in Cantonese, Mandarin, or English 7. Patients is absence of any cognitive impairment 8. Patients with a score of 6 minutes walking test (6MWT) ≤ 500 meters at baseline. \[rationale: a threshold value of 500 meters preoperative 6MWT predicts a higher risk of postoperative complications and prolonged LOS after lung resection\] 9. Engagement in less than 150 minutes of moderate aerobic activity per week in the past 3 months
Exclusion criteria
1. Patients who had engaged in at least 150 minutes of moderate aerobic activity or 75 minutes of vigorous aerobic activity per week in the past three months 2. Presence of another concurrent, actively treated malignancy 3. Presence of chronic obstructive pulmonary disease 4. Presence of significant comorbidities that impede ability to engage in exercise, such as congestive heart failure, orthopedic disorders of the lower limbs, respiratory failure, or the need for portable oxygen therapy for activities of daily living 5. Not having a smart device to receive WhatsApp messages
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change from baseline 6-minute walking distance from baseline to 3-month post-surgery | Baseline; 3-month post-surgery |
Secondary
| Measure | Time frame |
|---|---|
| Change from baseline 6-minute walking distance at 1-month post-surgery | Baseline; 1-months post-surgery |
| Length of postoperative hospital stay | 1-month post-surgery |
| Postoperative complication | 1-month post-surgery |
| Change from baseline functional assessment of cancer treatment - Lung (FACT-L) at post-intervention | Baseline; 2 weeks (post-intervention) |
| Change from baseline functional assessment of cancer treatment - Lung (FACT-L) at 1-month post-surgery | Baseline; 2 weeks (post-intervention); 1-month post-surgery |
| Change from baseline functional assessment of cancer treatment - Lung (FACT-L) at 3-months post-surgery | Baseline; 3-month post-surgery |
| Change from baseline international physical activity questionnaire (IPAQ) at post-intervention | Baseline; 2 weeks (post-intervention) |
| Change from baseline international physical activity questionnaire (IPAQ) at 1-month post-surgery | Baseline; 1-month post-surgery |
| Change from baseline 6-minute walking distance at post-intervention | Baseline; 2 weeks (post-intervention) |
| Change from baseline daily step count measured by pedometer at post-intervention | Baseline; 2 weeks (post-intervention) |
| Change from baseline daily step count measured by pedometer at 1-month post-surgery | Baseline; 1-month post-surgery |
| Change from baseline daily step count measured by pedometer at 3-month post-surgery | Baseline; 3-month post-surgery |
| Health-related quality of life for the cost-effectiveness analysis (EuroQol- 5 Dimension, EQ-5D-5L) | Baseline; 2 weeks (post-intervention); 1-month post-surgery; 3-month post-surgery |
| Health-related quality of life for the cost-effectiveness analysis (EuroQol-Visual Analog Score, EQ-VAS) | Baseline; 2 weeks (post-intervention); 1-month post-surgery; 3-month post-surgery |
| Physical activity self-efficacy (9-item Self-Efficacy for Exercise, SEE) | Baseline; 2 weeks (post-intervention); 1-month post-surgery; 3-month post-surgery |
| Financial toxicity (COmprehensive Score for financial Toxicity, COST questionnaire) | Baseline; 3-month post-surgery |
| Return to work (investigator-designed questionnaire) | 3-month post-surgery |
| Change from baseline international physical activity questionnaire (IPAQ) at 3-month post-surgery | Baseline; 3-month post-surgery |
Countries
Hong Kong
Contacts
Primary ContactChia-chin Lin, PhD
Backup ContactXinyi Xu, BSN
Outcome results
None listed