Atopic Dermatitis
Conditions
Keywords
Atopic eczema, palpebral dermatitis, patch-testing, ophthalmology, allergology, atopic dermatitis
Brief summary
Atopic dermatitis is a common inflammatory skin disease, resulting from genetical, immunological and environmental factors. Head and neck are among the most frequent involved areas, almost 50% in adult patients according to most publications. Palpebral involvement is also common and a source of major quality of life impairment for patients. However, the real frequency of this palpebral involvement is unknown, only estimated about 20% in few studies. The treatment of this location remains difficult, regarding to the thickness of palpebral skin and proximity of the eye. To our knowledge, no prospective studies about allergological skin tests (such as patch-tests) in atopic patients with palpebral involvement had been conducted. Finally, atopic dermatitis is frequently associated with ophthalmological diseases such as conjunctivitis, keratoconus or cataract, which belong to the minor criteria of Hanifin and Rakja classification. A better knowledge of the atopic dermatitis palpebral involvement and the associated factors seems to be needed to improve the treatment and the quality of life of patients
Interventions
OTHERStandard dermatology consultation
with clinical examination, score filling such as SCORAD and DLQI * Standard Allergy consultation, with clinical examination, research of atopic or allergic personal and familial history * Allergy skin testing: patch tests with the Standard European Battery and with some products bring by the patient if necessary, skin prick tests with aero allergens. Two reading of the patch tests will be performed, at H48 and H72. * ophthalmologic consultation with slit lamp examination and OSDI (self questionnaire)
Sponsors
University Hospital, Lille
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Atopic Dermatitis according to the revised Hanifin and Rakja criteria (UK Working Party) * Oral consent * Valid social insurance
Exclusion criteria
* Personal history of uncontrolled asthma * No social insurance * Protective measures * Age under 18 * Pregnancy or breast-feeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ratio of palpebral involvement in adult atopic dermatitis patients, regardless the severity of the disease | At Baseline, the initial consultation of dermatology |
Secondary
| Measure | Time frame |
|---|---|
| Association between allergic sensitization and severity of the atopic dermatitis | At 3 months, at the time of the reading of the tests either at 48 hours and 72 hours |
| Potential factors associated with palpebral involvement of the atopic dermatitis (socio-demographics factors, clinical factors, comorbidities, treatment, severity …) | At Baseline, (the initial consultation of dermatology ) and at 3 months during the consultation of allergology |
| Rate of relevant contact sensitization according to the skin testing and the clinical manifestations | At 3 months, at the time of the reading of the tests either at 48 hours and 72 hours |
| Description of the sensitization profile | At 3 months, at the time of the reading of the tests either at 48 hours and 72 hours |
| Clinical description of the palpebral involvement : acute eczema or chronic eczema | At Baseline, the initial consultation of dermatology |
| Clinical description of the ophthalmologic involvement and OSDI scoring | At 3 months during the time of the ophthalmologic consultation |
| Association between allergic sensitization and ophthalmologic involvement | At 3 months, at the time of the reading of the tests either at 48 hours and 72 hours |
| Association between ophthalmologic involvement and severity of the atopic dermatitis | At 3 months, at the time of the reading of the tests either at 48 hours and 72 hours |
| Rate of ophthalmologic comorbidities in association with palpebral involvement of the atopic dermatitis | At 3 months during the time of the ophthalmologic consultation |
Countries
France
Contacts
Primary ContactDelphine Staumont-Salle, MD,PhD
Outcome results
None listed