Behavior
Conditions
Keywords
Decision making
Brief summary
Adult smokers will be tested using behavioral and neuroimaging measures after smoking as usual and after overnight abstinence.
Interventions
OTHERsmoking abstinence
participants will be asked to not smoke for at least 12 hours
OTHERsmoking satiety
participants will be asked to smoke as usual
Sponsors
Wake Forest University Health Sciences
National Institute on Drug Abuse (NIDA)
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
Participants will be instructed to smoke as usual before one fMRI study visit (satiated state) and to abstain from using all tobacco/nicotine for 12 hours before the other fMRI study visit (abstinence and/or withdrawn state). The order of the satiated and abstinence/withdrawn study visits will be randomized and counterbalanced across participants.
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* Aged 18-55 years * Smokes cigarettes or e-cigarettes * Negative urine drug screen
Exclusion criteria
* Unstable or serious medical or mental health condition * History of serious head trauma * Pregnancy * Unsuitable for MRI * Weight \> 350 pounds (maximum allowed for MRI)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Effort Based Decision Making | approximately 2 weeks | number of high effort selections |
| Distress Tolerance Behavior | approximately 2 weeks | duration on measures of distress tolerance |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORMerideth Addicott, PhD
Wake Forest University Health Sciences
Baseline characteristics
| Characteristic | — |
|---|---|
| Age, Categorical <=18 years | 0 Participants |
| Age, Categorical >=65 years | 0 Participants |
| Age, Categorical Between 18 and 65 years | 5 Participants |
| Age, Continuous | 31.4 years STANDARD_DEVIATION 10.3 |
| cigarettes per day | 4.2 cigarettes per day STANDARD_DEVIATION 4.2 |
| Ethnicity (NIH/OMB) Hispanic or Latino | 0 Participants |
| Ethnicity (NIH/OMB) Not Hispanic or Latino | 5 Participants |
| Ethnicity (NIH/OMB) Unknown or Not Reported | 0 Participants |
| Race (NIH/OMB) American Indian or Alaska Native | 0 Participants |
| Race (NIH/OMB) Asian | 0 Participants |
| Race (NIH/OMB) Black or African American | 2 Participants |
| Race (NIH/OMB) More than one race | 0 Participants |
| Race (NIH/OMB) Native Hawaiian or Other Pacific Islander | 0 Participants |
| Race (NIH/OMB) Unknown or Not Reported | 0 Participants |
| Race (NIH/OMB) White | 2 Participants |
| Region of Enrollment United States | 2 participants |
| Sex: Female, Male Female | 0 Participants |
| Sex: Female, Male Male | 3 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk |
|---|---|---|
| deaths Total, all-cause mortality | 0 / 2 | 0 / 3 |
| other Total, other adverse events | 0 / 2 | 0 / 2 |
| serious Total, serious adverse events | 0 / 2 | 0 / 3 |
Outcome results
None listed