Behavior
Conditions
Keywords
Decision making
Brief summary
Adult smokers will be tested using behavioral and neuroimaging measures after smoking as usual and after overnight abstinence.
Interventions
OTHERsmoking abstinence
participants will be asked to not smoke for at least 12 hours
OTHERsmoking satiety
participants will be asked to smoke as usual
Sponsors
Wake Forest University Health Sciences
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
Participants will be instructed to smoke as usual before one fMRI study visit (satiated state) and to abstain from using all tobacco/nicotine for 12 hours before the other fMRI study visit (abstinence and/or withdrawn state). The order of the satiated and abstinence/withdrawn study visits will be randomized and counterbalanced across participants.
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* Aged 18-55 years * Smokes cigarettes or e-cigarettes * Negative urine drug screen
Exclusion criteria
* Unstable or serious medical or mental health condition * History of serious head trauma * Pregnancy * Unsuitable for MRI * Weight \> 350 pounds (maximum allowed for MRI)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Effort based decision making | through study completion, an average of 1 year | number of high effort selections |
| Distress tolerance behavior | through study completion, an average of 1 year | duration on measures of distress tolerance |
Countries
United States
Outcome results
None listed