DPP4 Inhibitor and Coronary Atherosclerosis in Patients Receiving Insulin Therapy

Effect of DPP4 Inhibitors on Coronary Atherosclerosis in Patients With Diabetes Mellitus on Insulin Therapy

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04825795

Enrollment

4007

Registered

2021-04-01

Start date

2010-01-01

Completion date

2021-03-30

Last updated

2023-02-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes Mellitus

Brief summary

The study aim is to evaluate whether DPP4-inhibitor could reduce coronary atherosclerosis assessed by CT scan in patients receiving insulin for diabetes mellitus. In this retrospective study, changes in obstructive coronary artery disease prevalence and coronary calcium burden between two coronary CT scans will be compared in patients with and without receiving DPP4-inhibitor.

Detailed description

This is a retrospective study using medical records in two hospitals affiliated to the Catholic University of Korea. Patients with diabetes mellitus who received insulin are retrospectively enrolled. Among those, only patients who underwent coronary CT scan for more than two times will be included. Included patients will be classified into DPP4-inhibitor group and no DPP4-inhibitor group according to the prescribed medication. The changes in obstructive coronary artery disease prevalence and coronary calcium score per one year will be compared between the two groups.

Interventions

DRUGDPP4-inhibitor

Prescription of DPP4-inhibitor during the period between the two coronary CT scan

DRUGNo DPP4-inhibitor

No prescription of DPP4-inhibitor during the period between the two coronary CT scan

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

19 Years to No maximum

Healthy volunteers

Inclusion criteria

* Diabetes mellitus * Receiving chronic insulin therapy (prescription of insulin pen) * Who underwent more than 2 times of coronary CT scan

Exclusion criteria

* Age \<18

Design outcomes

Primary

Measure	Time frame	Description
Prevalence of obstructive coronary disease	one year	Change in the prevalence of obstructive coronary disease, defined as \>50 percent stenosis in coronary CT scan

Secondary

Measure	Time frame	Description
Change in coronary calcium score	one year	Change in coronary calcium score, measured by two coronary CT scan per one year. Agatston score has minumum value of 0 and no maximum vavlue. Higher agatston score indicated severe calcification and worse outcome

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026