Anaphylaxis, Hemoptysis, Perioperative Complication
Conditions
Brief summary
Anaphylaxis is a severe and life-threatening complication during the perioperative period. Perioperative anaphylaxis is still associated with a significant mortality despite quick and efficient management using epinephrine, the mainstay of acute treatment. Experimental data and few case reports are suggesting that hemostasis, and more precisely platelets, could play a role in anaphylaxis. Our main hypothesis is that activation of the hemostatic system contributes to the severity of the reaction
Interventions
None listed
Sponsors
University Hospital, Strasbourg, France
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
2 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient, male or female, adult * In the perioperative period * In whom the diagnosis of anaphylactic shock is suggested * Patient is giving his consent to participate in the study
Exclusion criteria
* Subject under legal protection * Subject under guardianship or guardianship * Anemia less than 7 g /dl at the time of inclusion
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Platelet activation | As soon as possible after onset of anaphylaxis | Measurement of: Plasmatic serotonin level, Plasmatic PF-4 level, P-selectin expression (MFI, %), Platelet count |
Contacts
Primary ContactCharles-Ambroise TACQUARD, PHD
Backup ContactXavier DELABRANCHE, PHD
Outcome results
None listed