Oxygen Therapy
Conditions
Keywords
Oxygen therapy and Mortality
Brief summary
To assess the benefits and drawbacks of high versus low oxygen therapy on mortality and myocardial function in mechanically ventilated patients
Interventions
DRUGOxygen
* Decreasing fraction of inspired oxygen and its effect on mortality and myocardial function * administered by invasive mechanical ventilation with fraction of inspired oxygen between 0.21 and 1
Sponsors
Aswan University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* adults aged 18 years or older admitted to ICU and expected to receive mechanical ventilation beyond next calendar day
Exclusion criteria
* inclusion in other trial * severe acute respiratory distress syndrome at time of admission * acute Chronic obstructive airway disease exacerbation * pregnancy * Carbon monoxide poisoning * Guillain Barre syndrome
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Stroke volume in milliliters | Change from Baseline stroke volume At ICU admission and through study completion An average 6 months | Volume of blood in milliliters that is ejected from heart each second and measured By Echocardiography |
| Change in ejection fraction of heart in percentage | Change from baseline ejection fraction at icu admission and through study completion An Average 6 months | percentage of blood that's pumped out of a filled ventricle with each heartbeat And measured by echocardiography |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Stroke | From icu admission date to icu discharge date an average of 2 weeks | Cerebrovascular accidents |
| Mechanical Ventilator free days | From icu admission date to icu discharge date an average of 2 weeks | Days without mechanical ventilation |
| Shock | From icu admission date to icu discharge date an average of 2 weeks | Systolic blood pressure \< 90 mmHg |
| Surgery revision | From icu admission date to icu discharge date an average of 2 weeks | Surgical re exploration |
| Acute respiratory distress syndrome | From icu admission date to icu discharge date an average of 2 weeks | Acute persistent hypoxia with bilateral lung infiltrate due to non cardiac cause |
| ICU stay | From icu admission date to icu discharge date an average of 2 weeks | Duration of intensive care stay |
| Hospital stay | From icu admission date to icu discharge date an average of 2 weeks | Duration of hospital stay |
| Mortality | From icu admission date to icu discharge date an average of 2 weeks | Death of patient |
| Vasopressor | From icu admission date to icu discharge date an average of 2 weeks | Use of vasopressors as norepinephrine and epinephrine |
| Sepsis | From icu admission date to icu discharge date an average of 2 weeks | Systolic blood pressure \< 90 Respiratory rate \> 22 Heart rate \> 100 |
Countries
Egypt
Outcome results
None listed