Alveolar Ridge Preservation Using Amniotic Chorion Membrane

Alveolar Ridge Preservation Using Amniotic Chorion Membrane Alone or Combined With Xenograft (A Randomized Controlled Clinical Trial With Histological Evaluation)

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04824235

Enrollment

Registered

2021-04-01

Start date

2020-12-01

Completion date

2024-06-01

Last updated

2025-01-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alveolar Ridge Preservation

Brief summary

the present study is to compare the amniotic chorion membrane (ACM) alone versus the amniotic chorion membrane combined with xenograft for their efficacy in alveolar ridge preservation procedures regarding volumetric changes assessed by cone beam computed tomography (CBCT).

Interventions

OTHERAmniotic Chorion Membrane and Bio-Oss xenograft

Bioxclude Amniotic Chorion Membrane with xenograft (Bio-Oss) for ridge preservation

OTHERAmniotic Chorion Membrane only

Bioxclude Amniotic Chorion Membrane only

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

20 Years to 45 Years

Healthy volunteers

Inclusion criteria

* Patients require extraction of a non-restorable (premolar or anterior tooth) located in the maxillary arch and needs implant restoration. * Type two sockets will be selected as revealed by Cone beam computed tomography(CBCT) * Absence of any systemic disease or drugs that contraindicate oral surgery using Modified Cornell Medical Index * Male and female within age range of 20-45 years.

Exclusion criteria

* Smokers. * Patients with poor oral hygiene or non-compliant patients who are not willing to perform oral hygiene measures. * Pregnant and breast-feeding females. * Patients with acute peri-apical infection or sinus tract. * Vulnerable group of patients as handicapped patients, orphans,prisoners,etc

Design outcomes

Primary

Measure	Time frame	Description
Change in Bucco-lingual bone width	at baseline, 1 months and 4 months	Bone width will be measured using bone caliper and radiographically
Change in Corono-apical bone height	at baseline, 1 months and 4 months	Bone height using a pre-fabricated stent.
total bone volume change	at baseline, and 4 months	It will be evaluated by the use of 3D scans of patient dental models

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026