Cardiovascular Diseases, NSTEMI, STEMI
Conditions
Keywords
stress echocardiography, speckle tracking
Brief summary
Recovering blood flow to a coronary stenosis may improve left ventricular (LV) function in patients with coronary artery disease (CAD). However, the reported data about evaluation of LV function post-percutaneous coronary intervention (PCI) in CAD was limited. The aim of this study was to compare the LV function measured by 3 min low dose exercise stress echocardiography (ESE) combined 2D speckle tracking echocardiography (STE) in patients with CAD underwent PCI, and to identify factors affecting the change of LV function. Patients with CAD who underwent acute PCI were enrolled.
Detailed description
The assessment of temporal changes in systolic and diastolic regional left ventricle function by 2D-STE after successful reperfusion therapy of acute myocardial infarction (AMI).The estimated total number of participants is 90 patients with AMI and treated with successful percutaneous coronary intervention were included in this study. The echocardiographic measurements were performed in all patients within in-hotpital after PCI procedure, and then followed up at 7, 14, 30, 60 and 180 days after discharge. Recovery of regional systolic and diastolic myocardial function after acute myocardial infarction evaluated by ESE-STE.
Interventions
Stress echocardiography test. The standardized exercise test was conducted by 50-W semi-recumbent cycling for 3 min. Stress echocardiograph images were acquired at the third minute of cycling to ensure that subjects had reached a steady-state HR.
Sponsors
China Medical University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Inclusion criteria
* acute myocardial infarction diagnosed by a physician * undergoing percutaneous coronary intervention * Exercise testing and stress echocardiography are performed with the approval of the physician.
Exclusion criteria
* Severe cardiac valve disease * Left bundle branch block * Uncontrolled diabetes or hypertension * Orthopedics or other conditions that hinder from exercise * Uncontrolled sinus tachycardia (greater than 120 beats per minute)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The alterations of LV mechanics responses to a 3-min low dose exercise stress echocardiography following time. | detected at the in-hospital and the day 7, 14, 30, 60, and 180 after discharge. | The STE was performed at rest, during exercise and recovery to compare the changes of LV machines following discharge. The standardized exercise test was conducted by 50-W semirecumbent cycling (Cardiac Stress Table w/Angio) for 3 min. Stress echocardiograph images were acquired at the third minute of cycling to ensure that subjects had reached a steady-state HR. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The brain-type natriuretic peptide (BNP) levels | detected at the detected at the in-hospital and the day 7, 14, 30, 60, and 180 after discharge.ay 30, 60, and 180 after discharge. | BNP levels (picograms/milliliter) will be analysed from blood samples taken by a registered phlebotomist. |
| The high-sensitivity CRP (hsCRP) levels | detected at the detected at the in-hospital and the day 7, 14, 30, 60, and 180 after discharge.ay 30, 60, and 180 after discharge. | hsCRP levels (picograms/milliliter) will be analysed from blood samples taken by a registered phlebotomist. |
| The creatine kinase (CK) levels | detected at the detected at the in-hospital and the day 7, 14, 30, 60, and 180 after discharge.ay 30, 60, and 180 after discharge. | The CK levels (picograms/milliliter) will be analysed from blood samples taken by a registered phlebotomist. |
| The creatine kinase-MB (CK-MB) levels | detected at the detected at the in-hospital and the day 7, 14, 30, 60, and 180 after discharge.ay 30, 60, and 180 after discharge. | The CK-MB levels (picograms/milliliter) will be analysed from blood samples taken by a registered phlebotomist. |
| Cardiopulmonary fitness | detected at the day 30, 60, and 180 after discharge. | The graded exercise test (GXT) was performed with a cycle ergometer at the day 30 and 180 after discharge. The GXT comprised of unloaded pedaling for 2 min followed by a continuous increase in work rate (20-30 W) every 3 min until exhaustion (i.e., V˙ O2max). Minute ventilation (V˙ E), V˙ O2, and CO2 production (V˙ CO2) were measured breath-by-breath using a computer-based system (MasterScreen CPX; Cardinal Health Germany). |
| The left ventricle wall and cavity dimensions | detected at the detected at the in-hospital and the day 7, 14, 30, 60, and 180 after discharge.ay 30, 60, and 180 after discharge. | M-mode images were used to determine the LV wall and cavity dimensions at end-systole and end-diastole from a parasternal long axis view. |
| The left ventricle mass | detected at the detected at the in-hospital and the day 7, 14, 30, 60, and 180 after discharge.ay 30, 60, and 180 after discharge. | Measurements of LVmass and the short fraction index were automatically derived using standard equations as followed: LVmass(gm) = 0.77 X 10\^-3X \[(IVS + LVIDd +PW)\^3 - (LVIDd)\^3 + 2.4\] |
| The left ventricle ejection fraction | detected at the detected at the in-hospital and the day 7, 14, 30, 60, and 180 after discharge.ay 30, 60, and 180 after discharge. | LV ejection fraction (LVEF) was determined using the modified Simpson's method from the apical four-chamber views. |
| The left ventricle diastolic functions | detected at the detected at the in-hospital and the day 7, 14, 30, 60, and 180 after discharge.ay 30, 60, and 180 after discharge. | Analysis of Doppler pulsed wave was performed to determine diastolic transmitral blood flow velocities for peak early (E) and late (A) fillings and was also detected the diastolic mitral annular tissue velocities for peak early (E') and late (A') fillings. |
| The troponin I levels | detected at the detected at the in-hospital and the day 7, 14, 30, 60, and 180 after discharge.ay 30, 60, and 180 after discharge. | The troponin I levels (picograms/milliliter) will be analysed from blood samples taken by a registered phlebotomist. |
Countries
Taiwan
Contacts
Primary ContactLI-Wei Chou, PhD
Outcome results
None listed