Prostate Cancer Diagnosis
Conditions
Keywords
MRI, prostate, thermometry, laser, ablation
Brief summary
The objective of this project is to offer a very innovative solution for measuring temperature variations in MRI on the prostate. Multiparametric prostate MRI can detect target lesions, on which targeted biopsies are then performed. The use of a temperature mapping on the prostate in MRI would make it possible to evaluate a focal treatment of the prostate by laser under MRI guidance
Detailed description
Prostate MRI has become the benchmark examination to search for tumor targets, thanks to a multi-parameter protocol, including T2 sequences, diffusions, and T1 with gadolinium injection. A PIRADS prognostic score is performed on the different sequences and if the lesions are at high risk of malignancy (PIRADS 4 and 5), a targeted biopsy is performed. Minimally invasive ablations called focal treatments are developing more and more: HIFU, cryotherapy, laser, etc. Ultrasound remains the most widespread examination due to its availability, but with less sensitivity than MRI. Ablations are performed under ultrasound with fusion of MRI images In order to assess the ablation area under MRI, the measurement of temperature variations appears necessary to verify the effectiveness of ablation and the lesion volume. Temperature maps are feasible in cardiac MRI during radiofrequency. The thermal mapping MRI sequence is performed in cardiac MRI at the IHU in Bordeaux.
Interventions
DEVICEMRI thermometry
MRI sequence of 5 to 10 minutes to measure the variation of temprerature in the prostate
Sponsors
University Hospital, Bordeaux
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Intervention model description
MRI sequence of 5 to 10 minutes to measure the variation of temprerature in the prostate
Eligibility
Sex/Gender
MALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age ≥ 18 years old * Patient with indication of injected multi-parameter MRI for the diagnosis of prostate cancer. * Signed informed consent. * Person affiliated or beneficiary of health insurance
Exclusion criteria
* MRI contraindications (Pace Maker, metallic foreign body, metallic heart valve). * Contraindication to gadolinium salt, * Patient under legal protection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| signal noise ratio | End of MRI exam (hour 1) | the evaluation of the signal on the thermometry sequence |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| temperature variance | End of MRI exam (hour 1) | temperature variance measurements in a region of interest of the prostate |
| spatial distortion measurement | End of MRI exam (hour 1) | spatial distortion measurement |
Countries
France
Outcome results
None listed