Postmenopausal Women
Conditions
Brief summary
The association between Homocysteine (Hcy) levels and bone mineral density (BMD) has been debated. Some studies have found a relationship between increased Hcy plasma levels and BMD in contrast; other studies have not found a relationship. The purpose of our study was to investigate whether or not Hcy plasma levels are related to BMD in a group of postmenopausal women.
Interventions
DIAGNOSTIC_TESTDual-Energy X-ray Absorptiometry (DXA)
BMD expressed in absolute values as g/cm2 and T-scores
Sponsors
Fundación Santiago Dexeus Font
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
50 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Postmenopausal women * BMD measured by dual-energy X-ray absorptiometry (DXA)
Exclusion criteria
* Primary ovarian failure * Early menopause * Cardiovascular, liver, or renal diseases * Surgical menopause * History of cancer * Receiving treatment known to influence levels of Hcy or bone mineralization (folates or vitamin B12 supplements, menopausal hormonal treatment, corticosteroids, anticonvulsants, heparin, thiazide diuretics, and antiresorptive agents).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| BMD expressed in absolute values as g/cm2 | one year before or after Homocysteine levels |
| Lumbar spine T-score | one year before or after Homocysteine levels |
| Femoral neck T-score | one year before or after Homocysteine levels |
| Total hip T-score | one year before or after Homocysteine levels |
Countries
Spain
Outcome results
None listed