Emergence Delirium, Emergence Agitation, Postoperative Delirium
Conditions
Keywords
emergence agitation, postoperative agitation, postoperative delirium, postoperative cognitive dysfunction, emergence delirium
Brief summary
Perioperative neurocognitive disorders (PND) have been studying by clinicians, particularly by anesthesiologists, pretty long, however the most inspiring advancements were achieved during the last few decades. The most recent classification of PND which includes cognitive decline diagnosed before operation (described as neurocognitive disorder); any form of acute event (postoperative delirium) and cognitive decline diagnosed up to 30 days after the procedure (delayed neurocognitive recovery) and up to 12 months (postoperative neurocognitive disorder) was proposed in 2017. However at will one can notice at least one uncertainty that pertinent to the definition of delirium, emergency delirium and not mentioned in the classification discussed agitation. The objective of the study is to determine if there is a difference between emergence agitation and emergence delirium.
Interventions
Sponsors
Negovsky Reanimatology Research Institute
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
45 Years to 74 Years
Healthy volunteers
No
Inclusion criteria
* Age from 45 to 74 years * Undergoing elective orthopedic surgery * Provide written informed consent to participate in the PoD trial
Exclusion criteria
* Undergoing emergent/urgent surgery * Montreal Cognitive Assessment \< 18 points * History of mental disorders according ICD-11 * Treated with at least one psychotropic drug * Patients with neuromuscular disease * Inability to undergo preoperative assessment for any reason * Previously enrolled in PoD trial
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| frequency of postoperative delirium | 5 postoperative day | Percent of postoperative delirium |
| frequency of postoperative cognitive dysfunction | 7 postoperative day | Percent of postoperative cognitive dysfunction |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Length of postoperative delirium | 5 postoperative day | Day of the end of postoperative delirium - day of onset of postoperative delirium |
| Length of stay in ICU | 1 year | From ICU admission to ICU discharge |
| Length of hospitalization | 1 year | From operative day to hospital discharge |
| frequency of emergence agitation | immediately upon emergence from anesthesia | Percent of emergence agitation |
| MACCE | 30 day | Cardiac death or Myocardial infarction or Non-fatal cardiac arrest or Coronary revascularization or Cerebrovascular accident |
| 30-day mortality | 30 day | 30-day mortality |
| 1-year mortality | 1 year | 1-year mortality |
| MACE | 30 day | Cardiac death or Myocardial infarction or Non-fatal cardiac arrest or Coronary revascularization |
| frequency of emergence delirium | immediately upon emergence from anesthesia | Percent of emergence delirium |
Countries
Russia
Outcome results
None listed