Portal Hypertension
Conditions
Brief summary
The complications associated with portal hypertension in cirrhosis are the main cause of death in patients with cirrhosis. The level of portal venous pressure is closely related to the prognosis of patients. HVPG (hepatic venous pressure gradient) is the gold standard for predicting portal venous pressure and an important indicator for evaluating the efficacy of NSBBS. However, monitoring HVPG has many limitations，and the clinical application is also limited to a certain extent. Therefore, this study intends to clarify the guiding value of monitoring portal venous pressure in the clinical diagnosis and treatment of portal hypertension patients through a single-center, prospective and observational study. Therefore, this study intends to clarify the guiding value of monitoring portal venous pressure in the clinical diagnosis and treatment of portal hypertension patients through a single-center, prospective and observational study. At the same time, to explore the correlation between HVPG and PPG in cirrhosis patients at different stages and different etiologies, and to evaluate the role of spleen stiffness in predicting the severity of esophageal and gastric varices in patients with portal hypertension, and to find biomarkers to predict the risk of complications related to portal hypertension.
Interventions
OTHERmonitoring portal pressure gradient or hepatic venous pressure gradient
measuring portal pressure gradient or hepatic venous pressure gradient regularly
Sponsors
Nanfang Hospital, Southern Medical University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Inclusion criteria
* With chronic liver disease * Age 18-80 years * Patients who require a portal pressure measurement at the discretion of the treating physician * Voluntarily signed informed consent
Exclusion criteria
* With serious cardiopulmonary disease or other diseases affect survival * With severe renal dysfunction * Concomitant portal vein cavernous degeneration or extensive portal vein thrombosis * Women who are planning to become pregnant or who are pregnant or breastfeeding * The researcher judged that it was not suitable to participate in this study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Gastroesophageal varices bleeding | three years | Patients with gastroesophageal varices has hematemesis or melena, and active bleeding or red sign can be seen under endoscopy |
| Ascites | three years | Peritoneal effusion was seen under ultrasound |
| Hepatic encephalopathy | three years | Patients with altered consciousness or unresponsiveness, accompanied by elevated blood ammonia |
Secondary
| Measure | Time frame |
|---|---|
| Death or final follow-up time (3 years) | three years |
Countries
China
Contacts
Primary ContactXiaofeng Zhang
Outcome results
None listed