Multiple Sclerosis (MS)
Conditions
Keywords
spinal cord (SC) pathology, demyelinating lesions, Spinal cord MRI, Averaged magnetization inversion recovery acquisitions (AMIRA) sequence, Swiss MS Cohort (SMSC)
Brief summary
This study is to evaluate the sensitivity and intra-/inter-observer agreement of the averaged magnetization inversion recovery acquisitions (AMIRA) in spinal cord (SC) Multiple sclerosis (MS) lesion detection and to evaluate the additional clinical value of this sequence in clinical settings.
Detailed description
An averaged magnetization inversion recovery acquisitions (AMIRA) sequence was proposed for SC MRI. This MR-sequence delivers excellent contrast between the SC gray and white matter as well as between the SC and cerebrospinal fluid (CSF) in clinically feasible-acquisition times. Moreover, the high quality and in-plane resolution of AMIRA images allows for segmentation of the SC gray and white matter with high accuracy and reproducibility. This study is to evaluate the sensitivity and intra-/inter-observer agreement of the averaged magnetization inversion recovery acquisitions (AMIRA) in spinal cord (SC) Multiple sclerosis (MS) lesion detection and to evaluate the additional clinical value of this sequence in clinical settings.
Interventions
PROCEDURESC MRI
SC MRI (Averaged Magnetization Inversion Recovery Acquisitions (AMIRA), standard conventional SC MRI sequences, additional sequences for spinal cord MRI (sagittal-2D or 3D short tau inversion recovery, sagittal-2D or 3D phase-sensitive inversion recovery, 3D magnetization prepared 2 rapid acquisition gradient echoes (MPRAGE)). To evaluate the presences of ongoing inflammation (acute or chronic) in the SC of patients, 3D MPRAGE and 3D fluid-attenuated inversion recovery images after intravenous gadolinium (Gd) contrast administration (0.1 mmol per kg body weight) will be acquired.
12-item multiple sclerosis walking scale (MSWS-12) questionnaire: self-report measure of the impact of MS on the individual's walking ability
Sponsors
University Hospital, Basel, Switzerland
Freie Akademische Gesellschaft Basel
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Intervention model description
All participants (embedded within the currently ongoing Swiss MS Cohort (SMSC) study) will undergo a single visit including a clinical interview, neurological examination and MRI.
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Diagnosis of multiple sclerosis according to established international criteria * Steroid free period: \> 4 weeks * Participation in the Swiss MS Cohort (SMSC) study
Exclusion criteria
* . History of severe (other) neurological, internal or psychiatric disease with SC affection * MRI-related
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of SC lesions | one time assessment (60 minutes scheduled per patient for the MRI part including preparation time outside of the scanner and actual scanning time) | Number of SC lesions using AMIRA compared to gold-standard conventional SC MRI sequences |
| Inter-observer agreement on SC lesion count | one time assessment (60 minutes scheduled per patient for the MRI part including preparation time outside of the scanner and actual scanning time) | Inter-observer agreement with regard to lesion detection using AMIRA compared to gold-standard conventional SC MRI sequences. |
| Presence of ongoing inflammation (acute or chronic) in the SC | one time assessment (60 minutes scheduled per patient for the MRI part including preparation time outside of the scanner and actual scanning time) | Presence of ongoing inflammation (acute or chronic) in the SC 3D MPRAGE and 3D fluid-attenuated inversion recovery images after intravenous gadolinium (Gd) contrast administration (0.1 mmol per kg body weight) |
Countries
Switzerland
Contacts
CONTACTKatrin Parmar, PD Dr. med.
CONTACTCharidimos Tsagkas, Dr. med.
PRINCIPAL_INVESTIGATORKatrin Parmar, PD Dr. med.
University Hospital Basel, Department of Neurology
Outcome results
None listed