Speech, Consolidation
Conditions
Brief summary
The proposed studies focus on memory for speech movements and sounds and its relation to learning. Continuous theta-burst transcranial magnetic stimulation (cTBS) will be used to suppress activity in a region of pre-frontal cortex associated with somatic and auditory working memory (Brodmann area 46v) to test its involvement in learning.
Detailed description
This study will assess the relationship between sensory working memory and speech motor adaptation using a between subjects design. Participants will be assigned to one of two groups. Each group will undergo both auditory and somatosensory working memory tests. This will be followed by adaptation to altered auditory feedback. Using a different group of subjects, cTBS will be used to disrupt neural activity in Brodmann area 46v in ventrolateral prefrontal cortex to test its involvement in adaptation. One set of tests will focus on the effects of cTBS on both auditory and somatosensory working memory. A second set of tests will focus on the effects of cTBS on speech motor adaptation to altered auditory feedback. Both working memory and adaptation are assessed on 0 to 100 scales.
Interventions
BEHAVIORALAdaptation
Sensorimotor adaptation in speech
OTHERcTBS
continuous theta-burst stimulation
Sponsors
National Institute on Deafness and Other Communication Disorders (NIDCD)
Yale University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
21 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* right handed adults * no known physical or neurological abnormalities
Exclusion criteria
* patients with: * cardiac pacemaker * surgical clips or values on the heart * implants * metal or metallic fragments in any part of the body * pregnancy * claustrophobia * a personal or family history of epilepsy * currently taking antipsychotic drugs * currently taking antidepressant drugs * currently taking antianxiety drugs * history of concussion.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Speech Motor Learning | Performance as measured at the end of learning (single day experiment) | Learning is assessed on a 0 to 100 scale as change in speech sounds (speech formant frequencies). A score of 100 corresponds to complete adaptation. |
| Sensory Memory | Single day experiment | Sensory Memory is measured on a 0 to 100 scale. A score of 100 corresponds to perfect memory. |
Countries
Canada
Outcome results
None listed