Skip to content

Genetic Influences on Dental Maturation: A Twin Study

Genetic Influences on Dental Maturation: A Twin Study

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04817358
Enrollment
171
Registered
2021-03-26
Start date
2018-01-01
Completion date
2021-01-01
Last updated
2021-03-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental Age Estimation Methods

Brief summary

The genetics has been shown as one of the most important factor influencing the growth and development of the dentofacial complex. Dental development, one of the most reliable indicators of chronological age (CA), has been believed to be fundamentally influenced by genetics rather than environmental factors. As twins share genetic variation (100% for monozygotic and 50% for dizygotic twins) and were subjected to the similar environmental factors, the twin studies have been presented useful and effective method to researchers for investigating the influence of heredity on dental development and observing the similarities and differences among twin pairs. Evaluation of dental development is among the most commonly used and reliable method for dental age determination using the morphological parameters of teeth on dental radiographs. Dental maturity, defined as a dental age (DA), is very important in forensic anthropology to identify cases and in dentistry for planning pedodontic and orthodontic treatment, and also determining a child's growth and developmental status. There are many dental age estimation methods which are mostly based on the morphological evaluation of dental growth observed from dental radiographs in children In order to estimate dental age, Demirjian's, Willems' and Nolla's methods were used. All panoramic radiographs were scored by one observer to eliminate the inter-observer error.

Interventions

None listed

Sponsors

Suleyman Demirel University
Lead SponsorOTHER

Study design

Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL

Eligibility

Sex/Gender
ALL
Age
5 Years to 13 Years
Healthy volunteers
Yes

Inclusion criteria

* good quality of panoramic radiographs, presence of all permanent mandibular and maxillar teeth except the third molars * healthy children with normal eruption of teeth, * children with similiar etnic origin and socio-economic status

Exclusion criteria

* Children with any syndromes, congenital or developmental anomalies and systemic diseases, * Children undergoing or with previous orthodontic treatment history, * Children with tooth agenesis, dental trauma history

Design outcomes

Primary

MeasureTime frameDescription
Demirjian methodup to 3 yearsthe development of the seven left mandibular permanent teeth (except the third molar) were rated on the eight-stage scale from A to H. Each stage of mineralization was given a score, total dental maturity score was evaluated according to standard tables for boys and girls

Secondary

MeasureTime frameDescription
Willems methodup to 3 yearsWillems' method was determined using the Demirjian calcification stages but scores were evaluated according to Willems' specific tables

Other

MeasureTime frameDescription
Nolla methodup to 3 yearsIn the Nolla method, the development of seven left mandibular and maxillar teeth were defined on 10 stages. If the tooth was between stages an appropriate fraction (0.2, 0.5 or 0.7) was added. The total score was determined according to the tables prepared for girls and boys as recommended by Nolla

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026